CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free)

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GMP-TILCM31-1L

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Components

Cat. No.	Components	Size
GMP-CM3102A	CelThera™ GMP Immune Cell Expansion Medium (Phenol Red-free)	1000 mL
GMP-CM31S9	CelThera™ GMP lmmune Cell Supplement E	16 mL

Note: 1. A complimentary bottle of CelThera™ GMP Phenol Red Solution (0.5%) (Cat# GMP-PI1100) is supplied with this kit. For cell culture procedures requiring phenol red indicator, add 1.5 mL of this solution to 1 L of CelThera™ GMP Immune Cell Expansion Medium (Phenol Red-free) and mix thoroughly.

Product Details

CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) is a serum-free culture medium specifically developed to support human TIL cell culture. It is a serum-free, animal origin-free TIL cell maintenance and expansion medium.

Features

Serum-free, animal origin-free (AOF), and exogenous growth factors free.
Designed to support high-fold expansion of TIL cells.
Suitable for large-scale TIL cell expansion.
Contains only recombinant proteins as components, no antibiotics added during manufacturing.

Storage

CelThera™ GMP Immune Cell Expansion Medium (Phenol Red-free) is stable for 18 months when stored under 2-8°C, protect from light.
CelThera™ GMP lmmune Cell Supplement E is stable for 24 months when stored under -20°C or below, protect from light.

Shipping

Components may ship in separate packages with different temperature controls (dry ice or blue ice). Please inquire about the shipping cost. Inspect all parcels upon arrival.

ACRO Quality Management System

QMS(ISO, GMP)

Quality Advantages

Quality Control Process

Application Data

The CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) enables the high-efficiency expansion of TIL cells derived from tumors during the pre-REP phase.
During the pre-REP phase of TIL cell culture, the expansion data demonstrated that this GMP TIL Cell Expansion Kit (Phenol Red-free) (ACROBiosystems, Cat. No. GMP-TILCM31) not only achieved high-efficiency expansion but also exhibited superior overall expansion performance compared to existing commercial counterparts on the market.

The CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) enables high-efficiency expansion of TIL cells in the REP phase.
TIL expansion during the REP phase was performed using ACRO GMP Monoclonal Anti-Human CD3 Antibody (OKT3) (ACROBiosystems, Cat. No. GMP-MC0323) and GMP Monoclonal Anti-Human 4-1BB Antibody (ACROBiosystems, Cat. No. GMP-M41B35). The CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) (ACROBiosystems, Cat. No. GMP-TILCM31) demonstrated superior proliferation kinetics compared with commercially available products.

The CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) produces TIL cells with a high CD8⁺ T-cell composition and a minimal CD4⁺ population.
Human TILs were cultured in different media for 14 days. On day 14, TILs cultured in this GMP TIL Cell Expansion Kit (Phenol Red-free) (ACROBiosystems, Cat. No. GMP-TILCM31) demonstrated a higher proportion of CD8-positive cells and a lower proportion of CD4-positive cells compared to those in commercially available medium, while the proportion of CD3-positive cells showed no significant difference.

The CelThera™ GMP TIL Cell Expansion Kit (Phenol Red-free) delivers TIL cells with superior cytotoxic potency.
After 14 days of culture, the cytotoxic functionality of TILs was assessed. The results demonstrated that TILs expanded in the GMP TIL Cell Expansion Kit (Phenol Red-free) (ACROBiosystems, Cat. No. GMP-TILCM31) exhibited significantly higher cytotoxicity against the A375 melanoma cell line compared to those cultured in the commercially available medium.