Biotinylated Human IFN-alpha / beta R1 (28-230) Protein, His,Avitag™ (MALS verified)

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Cat. No. / Size
Price
Qty
IF1-H82E4-25ug
$360.00
IF1-H82E4-200ug
$1420.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1

  • Source

    Biotinylated Human IFN-alpha / beta R1 (28-230) Protein, His,Avitag (IF1-H82E4) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Pro 230 (Accession # P17181-1).

    Predicted N-terminus: Lys 28

    Request for sequence
  • Molecular Characterization

    IFN-alpha/beta R1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 27 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IFN-alpha/beta R1 SDS-PAGE

    Biotinylated Human IFN-alpha / beta R1 (28-230) Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IFN-alpha/beta R1 SEC-MALS

    The purity of Biotinylated Human IFN-alpha / beta R1 (28-230) Protein, His,Avitag (Cat. No. IF1-H82E4) is more than 90% and the molecular weight of this protein is around 40-55 kDa verified by SEC-MALS.

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Background

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Recent Advances

 
Drug Development Progress
  • English Name:

    Interferon-alpha/beta receptor alpha chain

  • Category:

  • Approved Drugs:

    5 Details

  • Drugs in Clinical Trials:

    0 Details

  • Highest Development Stage:

    Approved

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