Rat IFN-alpha/beta R2 Protein, His Tag

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Cat. No. / Size
Price
Qty
IFA-R52H1-100ug
$360.00
IFA-R52H1-1mg
$2380.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    IFNAR2, IFNARB, IFNABR, IFN-R-2, IFN-alpha, beta receptor 2

  • Source

    Rat IFN-alpha/beta R2 Protein, His Tag (IFA-R52H1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Ala 244 (Accession # M0R8H7-1).

    Predicted N-terminus: Phe 31

    Request for sequence
  • Molecular Characterization

    IFN-alpha/beta R2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.7 kDa. The protein migrates as 34-44 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    IFN-alpha/beta R2 SDS-PAGE

    Rat IFN-alpha/beta R2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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Background

Interferon alpha/beta receptor 2 (IFR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFBR and IFRB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFR2 can associate with IFR1 to form the type I interferon receptor. IFR2 is a receptor for interferons alpha and beta.IFR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFR2 influence susceptibility to hepatitis B virus (HBV) infection.

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