4-1BB Ligand

4-1BB Ligand

4-1BB Ligand Overview

Molecule Name
Tumor necrosis factor ligand superfamily member 9
Synonyms
4-1BB Ligand,TNFSF9,CD137L
Drug Development Progress
Drugs in Clinical Trials2
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
4-1BB ligand,4-1BBL
Background
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

4-1BB Ligand Product List

Species
  • Human(6)
  • Cynomolgus(1)
  • Mouse(1)
  • Rat(1)
Tag
  • Fc Tag(5)
  • Fc Tag & Avi Tag(2)
  • His Tag & Flag Tag(2)
Host
  • HEK293(9)
Conjugate
  • Unconjugated(7)
  • Biotin-labeled(2)
Grade
  • RUO(5)
  • PG (pre-GMP)(3)
  • GMP(1)
Low Endotoxin
  • Yes(2)
  • No(7)
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
RTX-224RTX-224Phase 2 ClinicalRubius Therapeutics Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms
Details
RP-3RP-3Phase 2 ClinicalReplimune Inc
Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck
Details
Customer Reviews
  • P***l2025-05-30
    Hi, I work for a start-up company, Nkure Therapeutics, in Bangalore. We have used GMP-4-1BBL from AcroBio and it worked well in our hands for a therapeutic dose. We culture primary cells as such NK cells to provide a cell therapy against cancer. We are happy with the service and the product quality as well. We compared the data of NK cell expansion with Croyez 4-1-BBL and AcroBio 4-1-BBL and realized there is no difference in the potency, however there is a huge difference in the price. AcroBio provides smaller pack size with a good price range as well.
  • a***n2025-02-06
    Your FACS antibodies of great. worked greatly to study immune cell and activation markers study with extradentary available conjugates for Flow cytometry