Alpha-Synuclein Proteins & Cell Lines

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Alpha-Synuclein Overview

Molecule Name

Synuclein alpha

Synonyms

SNCA,NACP,PARK1,alpha-Synuclein

Drug Development Progress

Drugs in Clinical Trials25

Approved Drugs0

Highest Development StagePhase 3 Clinical

Target Synonym

Truncated Alpha Synuclein，Α-Synuclein，PARK1，SNCA，Synuclein Alpha，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor，Non A-Beta Component Of AD Amyloid，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，Î±-Synuclein，PARK4，alpha-Synuclein

Background

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Alpha-Synuclein Product List

Molecule	Cat. No.	Product Name	Species	Host	Purity	Activity	Size&Price
Alpha-Synuclein	HOT ALN-H5253	Human Alpha-Synuclein Protein, Fc Tag (MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISA	$165.00 200ug
Alpha-Synuclein	HOT ALN-H5114	Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free	Human	E. coli	SDS-PAGE	CELL BASE	$360.00 100ug
Alpha-Synuclein	HOT ALN-H5115	Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free	Human	E. coli	SDS-PAGE	CELL BASEThT	$360.00 100ug
Alpha-Synuclein	HOTAvitag ALN-H82H8	Biotinylated Human Alpha-Synuclein Protein, His,Avitag™ (MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISA	$360.00 25ug
Alpha-Synuclein	HOT ALN-H5214	Human Alpha-Synuclein Protein, Tag Free, low endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISA	$305.00 200ug
Alpha-Synuclein	HOT ALN-H52H8	Human Alpha-Synuclein Protein, His Tag, low endotoxin	Human	E. coli	SDS-PAGE		$165.00 200ug
Alpha-Synuclein	ALN-C52H5	Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)	Cynomolgus	E. coli	MALSSDS-PAGE	ELISA	$185.00 200ug
Alpha-Synuclein	ALN-H5116	Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)	Human	E. coli	MALSSDS-PAGE	ELISA	$290.00 200ug
Alpha-Synuclein	ALN-H5117	Human Alpha-Synuclein (E46K) Protein, Tag Free	Human	E. coli	SDS-PAGE	ELISA	$290.00 200ug
Alpha-Synuclein	ALN-H51H4	Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag	Human	E. coli	SDS-PAGE	CELL BASEThT	$350.00 100ug

Alpha-Synuclein >

Hot

Human Alpha-Synuclein Protein, Fc Tag (MALS verified)

Cat. No. ALN-H5253

Species

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$165.00

Alpha-Synuclein >

Hot

Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free

Cat. No. ALN-H5114

Species

Human

Host

E. coli

Purity

SDS-PAGE

Activity

CELL BASE

$360.00

Alpha-Synuclein >

Hot

Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free

Cat. No. ALN-H5115

Species

Human

Host

E. coli

Purity

SDS-PAGE

Activity

CELL BASEThT

$360.00

Alpha-Synuclein >

HotAvitag

Biotinylated Human Alpha-Synuclein Protein, His,Avitag™ (MALS verified)

Cat. No. ALN-H82H8

Species

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$360.00

Alpha-Synuclein >

Hot

Human Alpha-Synuclein Protein, Tag Free, low endotoxin (MALS verified)

Cat. No. ALN-H5214

Species

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$305.00

Alpha-Synuclein >

Hot

Human Alpha-Synuclein Protein, His Tag, low endotoxin

Cat. No. ALN-H52H8

Species

Human

Host

E. coli

Purity

SDS-PAGE

$165.00

Alpha-Synuclein >

Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)

Cat. No. ALN-C52H5

Species

Cynomolgus

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$185.00

Alpha-Synuclein >

Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)

Cat. No. ALN-H5116

Species

Human

Host

E. coli

Purity

MALSSDS-PAGE

Activity

ELISA

$290.00

Alpha-Synuclein >

Human Alpha-Synuclein (E46K) Protein, Tag Free

Cat. No. ALN-H5117

Species

Human

Host

E. coli

Purity

SDS-PAGE

Activity

ELISA

$290.00

Alpha-Synuclein >

Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag

Cat. No. ALN-H51H4

Species

Human

Host

E. coli

Purity

SDS-PAGE

Activity

CELL BASEThT

$350.00

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FAQ

Why is the 218 linker specifically chosen over other peptide sequences in scFv-based therapies?

A major reason for choosing the 218 linker is its ability to enhance the stability of the scFv. Research indicates that scFvs containing this specific linker show reduced aggregation and are more resistant to proteolysis (breakdown by enzymes) in vitro compared to some other synthetic linkers.

How can I ensure my anti-linker antibody meets regulatory standards for global clinical manufacturing?

ACROBiosystems supports regulatory compliance by providing GMP regulatory support files and facilitating both online and offline audits of our GMP manufacturing facilities. Our products are developed referencing international guidelines , ensuring your critical raw materials meet the stringent safety and quality requirements of global health authorities.

How does an anti-G4S linker antibody compare to Protein L for detecting scFvs?

Protein L binds to the kappa light chain of scFvs, but it is not compatible with scFvs using lambda chains or those where the binding site is obscured. An anti-G4S linker antibody targets the peptide bridge directly, making it a more specific tool for any construct utilizing the G4S motif, regardless of the light chain type.

When is it necessary to use "GMP-grade" anti-G4S linker antibodies?

GMP grade is necessary when the antibody is used in clinical stage manufacturing or QC release testing, because regulatory agencies require GMP compliant materials to ensure patient safety, batch to batch consistency, and full traceability—these are mandatory for IND/BLA submissions. For CAR T clinical programs, GMP grade is therefore required.

Why choose a Rabbit Monoclonal Anti-G4S antibody over traditional polyclonal options?

Polyclonals are a heterogeneous mix, recognize multiple epitopes, but suffer from batch variability. Monoclonals come from a single clone, recognize one epitope, ensuring specificity and consistency. Recombinant rabbit monoclonals, derived from stable DNA, avoid hybridoma drift and guarantee reliable supply. For Anti‑G4S linker detection in CAR‑T manufacturing, this reproducibility is essential for standardized QC—making the recombinant rabbit monoclonal the preferred choice.

Asset Licensing Opportunity

Resources

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Buntanetap	ANVS-405; ANVS-401	Phase 3 Clinical	Raptor Pharmaceutical	Alzheimer Disease; Chronic Traumatic Encephalopathy; Cognitive Dysfunction; Down Syndrome; Frontotemporal Dementia; Parkinson Disease	Details
Amlenetug	Lu AF-82422; Lu AF82422; Lu-AF82422	Phase 3 Clinical	Genmab A/S, H. Lundbeck A/S	Multiple System Atrophy; Parkinson Disease	Details
Prasinezumab	PRX-002; RG-7935; NEOD-002; RO-7046015	Phase 3 Clinical	Prothena	Parkinson Disease	Details
Kenterin	ENT-01; kenterin; Enterin-01	Phase 2 Clinical	Enterin Inc	Constipation; Dementia; Parkinson Disease	Details
PBT-434	PBT-434; ATH-434	Phase 2 Clinical	Prana Biotechnology Ltd	Multiple System Atrophy	Details
MT101-5	MT101-5	Phase 2 Clinical	Mthera Pharma Co Ltd	Parkinson Disease	Details
AMDX-2011P	AMDX2011P; AMDX-2011P	Phase 2 Clinical	Amydis Inc	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Cerebral Amyloid Angiopathy; Glaucoma, Open-Angle; Parkinson Disease	Details
ACI-7104	ACI-7104.056; ACI-7104	Phase 2 Clinical	Ac Immune Sa	Parkinson Disease	Details
Minzasolmin	UCB-1332; NPT200-11; DLX-313; DLX313; UCB-0599	Phase 2 Clinical	Neuropore Therapies Inc	Parkinson Disease	Details
Exidavnemab	PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164	Phase 2 Clinical	Bioarctic Ab	Multiple System Atrophy; Parkinson Disease	Details
Emrusolmin	TEV-56286; TEV-'286; Anle-138b; TEV-286	Phase 2 Clinical	Ludwig-Maximilians-University, Max Planck Institute for Biophysical Chemistry	Multiple System Atrophy; Parkinson Disease	Details
ION-464	BIIB-101; IONIS-BIIB6 Rx; ION-464	Phase 1 Clinical	Ionis Pharmaceuticals Inc	Multiple System Atrophy	Details
UB-312	UB-312	Phase 1 Clinical	United Neuroscience Ltd	Multiple System Atrophy; Parkinson Disease; Parkinsonian Disorders	Details
SAR-446159	SAR-446159; ABL-301	Phase 1 Clinical	Abl Bio Inc	Parkinson Disease	Details
SST-001	SST001; SST-001; 18F-FD4	Phase 1 Clinical	SynuSight Biotech (Shanghai) Co Ltd	Diagnostic agents; Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies	Details
18F-CP6A	18F-CP6A	Phase 1 Clinical	Shenzhen Braegen Pharmaceutical Co Ltd	Synucleinopathies	Details
AB-16	AB-16	Phase 1 Clinical	Autotac Bio Inc	Parkinson Disease	Details
ACI-12589	ACI-12589; a-syn-PET tracer (AC Immune); [18F]MNI-1216; [18F]ACI-12589	Phase 1 Clinical	Ac Immune Sa, Biogen Inc, Invicro Llc	Lewy Body Disease; Multiple System Atrophy; Parkinson Disease; Synucleinopathies	Details
PK-081	PK081; PK-081	Phase 1 Clinical	PharmaKure Ltd	Parkinson Disease	Details
[11C]SY-08	[11C]SY-08; [11C]SY08	Phase 1 Clinical	Massachusetts General Hospital	Lewy Body Disease; Multiple System Atrophy; Parkinson Disease	Details
SNP201	SNP201; SNP-201	Phase 1 Clinical	SciNeuro Pharmaceuticals	Parkinson Disease	Details
[18F]UCB-2897	UCB-2897; [18F]UCB-2897	Phase 1 Clinical	Invicro Llc	Multiple System Atrophy; Parkinson Disease	Details
ACI-3847	ACI-3847; 18F-ACI-3847	Phase 1 Clinical	Ac Immune Sa, Biogen Inc	Neurodegenerative Diseases; Parkinson Disease	Details
UCB-7853	UCB-7853	Phase 1 Clinical	Ucb Biopharma Srl	Parkinson Disease	Details
Syneuro (Indus Biotech)		Clinical	Indus Biotech Pvt Ltd	Parkinson Disease	Details