user
cart
menu
orderQuote Inquiry / OrdercartCart
letter
Sign InRegister
langEnglisharrow

Axl

Axl

Axl Overview

Molecule Name
AXL receptor tyrosine kinase
Synonyms
AXL,UFO
Drug Development Progress
Drugs in Clinical Trials27
Approved Drugs2
Highest Development StageApproved
Target Synonym
EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
Background
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Axl Product List

Species
  • Human（3）
  • Cynomolgus（1）
Tag
  • His Tag（2）
  • Fc Tag（1）
  • Fc Tag & Avi Tag（1）
Host
  • HEK293（4）
Conjugate
  • Unconjugated（3）
  • Biotin-labeled（1）
Grade
  • RUO（4）
Low Endotoxin
  • No（4）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Axl
HOTAvitag
AXL-H82F9
Biotinylated Human AXL Protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Axl
AXL-C52H3
Cynomolgus Axl Protein, His Tag (SPR verified)
Cynomolgus
HEK293
SDS-PAGE
SPR

$310.00

100ug
Axl
AXL-H5226
Human Axl Protein, His Tag (SPR verified)
Human
HEK293
SDS-PAGE
SPR

$260.00

200ug
Axl
AXL-H5253
Human Axl Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPR

$310.00

100ug
You Have Viewed 1-4 Of 4 Results
  • 1

Can’t find what you need?

Submit your requirements and our technical
team will help.

Product InquiryRequest Customization
Asset Licensing Opportunity

Project Cooperation

Project NameDrug TypeTherapeutic AreaIndicationStageRights Area
AXL inhibitorSmall moleculeOncology/CancerSTK11_mut NSCLC,other cancersPhase IGlobal
Project Name
AXL inhibitor
Drug Type
Small molecule
Therapeutic Area
Oncology/Cancer
Indication
STK11_mut NSCLC,other cancers
Stage
Phase I
Rights Area
Global
Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
BatiraxceptS6-500c; 3D-229; 3D229; 3D-299; Ruga-S6; AB-007; AVB 500; AVB-500; Aravive S-6; AVB-S6-500Phase 3 ClinicalAravive Inc
Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours; Uterine Neoplasms
Details
KC1036KC1036; KC-1036Phase 3 ClinicalBeijing Konruns Pharmaceutical Co Ltd
Adenocarcinoma; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Hematologic Neoplasms; Neoplasm Metastasis; Sarcoma, Ewing; Solid tumours; Thymus Neoplasms
Details
SitravatinibMG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516Phase 3 ClinicalMirati Therapeutics Inc
Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma
Details
ButylidenephthalideNSC-325307; LF-001 (Everfront Biotech); EF-001; HK-001; BDPHPhase 3 ClinicalEverfront Biotech Co Ltd
Amyotrophic Lateral Sclerosis; Glioblastoma; Glioma
Details
Ningetinib TosylateCT-053-PTSA; CT-053Phase 2 ClinicalHec Pharm Co Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Intestinal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Solid tumours; Stomach Neoplasms
Details
Mecbotamab vedotinBA-3011; BA3011; BA 3011Phase 2 ClinicalBioatla
Carcinoma, Non-Small-Cell Lung; Dermatofibrosarcoma; Ovarian Neoplasms; Sarcoma
Details
Merestinib5OGS5K699E; LY-2801653Phase 2 ClinicalEli Lilly And Company
Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours
Details
TamnorzatinibONO-7475Phase 2 ClinicalOno Pharmaceutical Co Ltd
Carcinoma, Non-Small-Cell Lung; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pancreatic Neoplasms; Solid tumours
Details
BemcentinibBGB-324; R-428; BGB-3234Phase 2 ClinicalRigel Pharmaceuticals Inc
Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Coronavirus Disease 2019 (COVID-19); Glioblastoma; Inflammatory Breast Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Pancreatic Neoplasms; Triple Negative Breast Neoplasms
Details
Enapotamab vedotinAXL-107-MMAEPhase 2 ClinicalGenmab A/S, Seagen Inc
Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Melanoma; Ovarian Neoplasms; Sarcoma; Solid tumours; Thyroid Neoplasms; Uterine Cervical Neoplasms
Details
CD73/AXL.HypoSti.CAR-T cells therapy (Pla General Hospital)Phase 2 ClinicalPla General Hospital
Solid tumours
Details
FC-084-CSAFC084CSA; FC-084-CSAPhase 2 ClinicalFindCure Biosciences (ZhongShan) Co Ltd
Solid tumours
Details
AdrixetinibQ-702Phase 2 ClinicalLead Discovery Center GmbH, Max Planck Institute of Biochemistry, Vichem Chemie
Blastic Plasmacytoid Dendritic Cell Neoplasm; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Erdheim-Chester Disease; Esophageal Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms; Neoplasms, Plasma Cell; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms; Waldenstrom Macroglobulinemia
Details
DubermatinibTP-0903Phase 1 ClinicalSumitomo Dainippon
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Melanoma; Ovarian Neoplasms; Solid tumours
Details
INCB-081776INCB-81776; INCB-081776Phase 1 ClinicalIncyte Corp
Solid tumours; Squamous Cell Carcinoma of Head and Neck
Details
BPI-9016BPI-9016; BPI-9016MPhase 1 ClinicalBetta Pharmaceuticals Co Ltd
Carcinoma, Non-Small-Cell Lung; Solid tumours
Details
A-416A416; A-416Phase 1 ClinicalKlus Pharma Inc
Solid tumours
Details
NTQ-2494NTQ2494; NTQ-2494Phase 1 ClinicalNanjing Zhengda Tianqing Pharmaceutical Co Ltd
Hematologic Neoplasms; Leukemia, Myeloid, Acute; Solid tumours
Details
CTS-2016CTS-2016Phase 1 ClinicalCytosinLab Therapeutics Co Ltd
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Details
LigritinibAB-801Phase 1 ClinicalArcus Biosciences Inc
Neoplasms
Details
XZB-0004XZB-0004; SLC-0211; SLC-391Phase 1 ClinicalXuanzhu (Shijiazhuang) Biotechnology Co Ltd
Carcinoma, Non-Small-Cell Lung; Foodborne Diseases; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic Syndromes; Solid tumours
Details
NP-107NP107; NP-107Phase 1 ClinicalShanghai Nawei Biotechnology Co Ltd
Solid tumours
Details
TT-00973TT-00973Phase 1 ClinicalTransThera Sciences (Nanjing) Inc
Solid tumours
Details
AGX-0073AGX-0073Phase 1 ClinicalShanghai Aojian Biological Technology Co Ltd
Solid tumours
Details
Denfivontinib HydrochlorideSKI-G-801; G-801; G-749 HydrochloridePhase 1 ClinicalGenosco
Leukemia, Myeloid, Acute; Solid tumours
Details
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology)NP-01Phase 1 ClinicalNanjing Nadingfei Pharmaceutical Technology Co Ltd, Shijiazhuang No 4 Pharmaceutical Co Ltd
Liver Neoplasms; Lung Neoplasms; Solid tumours; Stomach Neoplasms
Details
NPS-1034HOPE-777; KDDF-201111-02Neopharma Ltd
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
Gilteritinib FumarateASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code)ApprovedAstellas Pharma IncXospataJapanLeukemia, Myeloid, AcuteAstellas Pharma Inc2018-09-21
Carcinoma, Non-Small-Cell Lung; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Renal Insufficiency; Solid tumours
Details
Cabozantinib S-malateXL-184; BMS-907351; RO7047650; RO-7047650ApprovedExelixis IncCometriq, CabometyxUnited StatesThyroid Neoplasms; Carcinoma, NeuroendocrineExelixis Inc2012-11-29
Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin
Details
Customer Reviews