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Cadherin-17

Cadherin-17

Cadherin-17 Overview

Molecule Name
Cadherin-17
Synonyms
Cadherin-17,CDH17,HPT-1,LI-cadherin
Drug Development Progress
Drugs in Clinical Trials17
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Liver-intestine cadherin，HPT-1，Intestinal peptide-associated transporter HPT-1，LI-cadherin，HPT-1 Cadherin，Cadherin 17， LI Cadherin (Liver-Intestine)，HPT1，Human Intestinal Peptide-Associated Transporter HPT-1，LI Cadherin，Cadherin，Cadherin 17，Human Peptide Transporter 1
Background
Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Cadherin-17 Product List

Species
  • Human（21）
  • Mouse（4）
  • Cynomolgus（3）
  • Rat（1）
  • Rhesus macaque（1）
Tag
  • Fc Tag（12）
  • His Tag（11）
  • His Tag & Avi Tag（4）
  • Fc Tag & Avi Tag（2）
  • Mouse IgG Fc Tag（1）
Host
  • HEK293（30）
Conjugate
  • Unconjugated（23）
  • Biotin-labeled（6）
  • FITC Labeled（1）
Grade
  • RUO（30）
Low Endotoxin
  • Yes（1）
  • No（29）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
Cadherin-17
HOT
CA7-H52H4
Human Cadherin-17 / CDH17 Protein, His Tag, low endotoxin (Active)
Human
HEK293
SDS-PAGE
ELISA

$420.00

100ug
Cadherin-17
HOT
CA7-M52H5
Mouse Cadherin-17 / CDH17 Protein, His Tag (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISA

$480.00

100ug
Cadherin-17
HOTAvitag
CA7-H52E6
Biotinylated Human Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$505.00

25ug
Cadherin-17
HOT
CA7-C52H3
Cynomolgus Cadherin-17 / CDH17 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$410.00

100ug
Cadherin-17
HOT
CA7-H52H3
Human Cadherin-17 / CDH17 Protein, His Tag
Human
HEK293
SDS-PAGE
ELISASPR

$480.00

100ug
Cadherin-17
CA7-C5253
Cynomolgus Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$430.00

100ug
Cadherin-17
Avitag
CA7-C82E9
Biotinylated Cynomolgus Cadherin-17 / CDH17 Protein, His,Avitag™
Cynomolgus
HEK293
SDS-PAGE
ELISA

$400.00

25ug
Cadherin-17
CA7-H5253
Human Cadherin-17 / CDH17 Protein, Fc Tag (Active, MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$410.00

100ug
Cadherin-17
CA7-H5254
Human Cadherin-17 / CDH17 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISA

$245.00

100ug
Cadherin-17
CA7-H5255
Human Cadherin-17 / CDH17 (450-566) Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE

$245.00

100ug
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FAQ

Does an FDA DMF mean a Mycoplasma Detection Kit is FDA approved?

No. FDA states that DMFs are neither approved nor disapproved. Their technical contents are reviewed in connection with regulatory applications that reference the DMF.

The available flu antibodies do not meet my specificity requirements. Is it possible to customize antibodies?

Yes, we offer customized antibody services. Our library includes over 100 antibodies, allowing us to efficiently identify and match products that align with your specific needs.

Is NAT recognized for mycoplasma testing?

Yes. Major pharmacopoeias recognize NAT-based methods for mycoplasma testing. Ph. Eur. 2.6.7 provides a framework for the use of NAT, while USP <77> specifically addresses mycoplasma nucleic acid amplification tests. Appropriate method validation and suitability assessment are required for the intended application.

Are the HA and NA proteins provided by your company in their native structure?

The HA protein is provided in its trimeric structure, while the NA protein is in a tetrameric structure. This mimics the native structure of viral surface proteins and ensures reliability for your research.

How Should I Select a Mycoplasma qPCR Kit for Biopharmaceutical QC?

Consider analytical sensitivity and specificity, Mollicutes coverage, matrix compatibility, workflow time, internal controls, validation data, and regulatory documentation. For regulated applications, technical and regulatory support should also be considered alongside assay performance.

The flu HA antigen protein HA1-V52H3, HAE-V52H3, and HA2-V52H5 all include trimeric components.

The mentioned products all feature trimeric components at the C-terminus, while the antibody binding epitopes are at the N-terminus, ensuring no interference with binding. ELISA validation shows good binding activity, with specific data available on the product webpage.
Asset Licensing Opportunity

Antibody Project Trading Platform

Project NameProject StageMolecule TypeMolecule SourceDisease AreaIndication
CDH17 mAb - 01PCCMonoclonalHumanized MouseSolid TumorColorectal cancer,Gastric Cancer
Project Name
CDH17 mAb - 01
Project Stage
PCC
Molecule Type
Monoclonal
Molecule Source
Humanized Mouse
Disease Area
Solid Tumor
Indication
Colorectal cancer,Gastric Cancer
Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
LM-350LM-350Phase 2 ClinicalLaNova Medicines Ltd
Gastrointestinal Neoplasms; Neoplasms; Solid tumours
Details
7MW-49117MW-4911Phase 2 ClinicalMabwell (Shanghai) Bioscience Co Ltd
Colorectal Neoplasms; Gastrointestinal Neoplasms; Solid tumours
Details
CM518D1CM518D1; CM-518-D-1Phase 2 ClinicalKeymed Biosciences Co Ltd
Solid tumours
Details
HS-20110HS20110; HS-20110Phase 2 ClinicalChangzhou Hengbang Pharmaceutical Co Ltd, Shanghai Hansoh Biomedical Co Ltd
Carcinoma, Renal Cell; Colorectal Neoplasms; Solid tumours
Details
AMT-676AMT-676Phase 2 ClinicalMultitude Therapeutics Inc
Colorectal Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
CHM-2101CDH17-CAR T; CHM-2101; CHM2101; CHM-2101 CAR-T cellsPhase 2 ClinicalUniversity Of Pennsylvania
Colorectal Neoplasms; Gastrointestinal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Stomach Neoplasms
Details
MRG-007MRG-007; ARR-217Phase 2 ClinicalLepu Biopharma Co Ltd
Colorectal Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
BI-905711BI-905711Phase 1 ClinicalBoehringer Ingelheim International Gmbh
Cholangiocarcinoma; Gastrointestinal Neoplasms; Pancreatic Neoplasms
Details
CabotamigARB-202Phase 1 ClinicalArbele Corp
Biliary Tract Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal adenocarcinoma; Gastrointestinal Neoplasms; Liver Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Stomach Neoplasms
Details
HDM-2017HDM-2017; HDM2017Phase 1 ClinicalHangzhou Zhongmei Huadong Pharmaceutical Co Ltd
Colorectal Neoplasms; Solid tumours
Details
SIM-0609SIM-0609; SIM0609Phase 1 ClinicalShanghai Xianwei Pharmaceutical Technology Co Ltd
Gastrointestinal Neoplasms; Neoplasm Metastasis; Solid tumours
Details
UCLH-801UCLH-801Phase 1 ClinicalUTC Therapeutics Inc
Biliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Neoplasms; Stomach Neoplasms
Details
Anti-CDH17 CAR-T cells Therapy (Guangzhou Bio-Gene Technology)Phase 1 ClinicalGuangzhou Bio-Gene Technology Co Ltd
Solid tumours
Details
Anti-CDH17 CAR-T Cell therapy (UTC Therapeutics)Phase 1 ClinicalUTC Therapeutics Inc
Solid tumours
Details
YL-217YL217; YL-217Phase 1 ClinicalMediLink Therapeutics Co Ltd
Solid tumours
Details
TORL-3-600TORL-3-600Phase 1 ClinicalTorl Biotherapeutics LLC
Colorectal Neoplasms; Solid tumours
Details
CDH17 - IHC Test(Arbele)ClinicalArbele Corp
Gastrointestinal Neoplasms
Details
Customer Reviews