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CD117

CD117 Overview

English Name	Stem cell growth factor receptor	Approved Drugs	16
Drugs in Clinical Trials	31	Target Synonym	EC 2.7.10，EC:2.7.10.1，MASTC，KIT Proto-Oncogene Receptor Tyrosine Kinase，V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein，p145 c-kit，SCFR，KIT，Proto-Oncogene C-Kit，Proto-Oncogene Tyrosine-Protein Kinase Kit，Soluble KIT Variant 1，C-Kit Protooncogene，CD117 Antigen，Piebald Trait，EC 2.7.10.1，C-Kit，CD117，Proto-Oncogene Proteins c-kit，Mast/stem cell growth factor receptor Kit，PBT，Piebald trait protein，Tyrosine-protein kinase Kit，KIT Proto-Oncogene， Receptor Tyrosine Kinase，v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Highest Development Stage	Approved

English Name	Stem cell growth factor receptor
Target Synonym	EC 2.7.10，EC:2.7.10.1，MASTC，KIT Proto-Oncogene Receptor Tyrosine Kinase，V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein，p145 c-kit，SCFR，KIT，Proto-Oncogene C-Kit，Proto-Oncogene Tyrosine-Protein Kinase Kit，Soluble KIT Variant 1，C-Kit Protooncogene，CD117 Antigen，Piebald Trait，EC 2.7.10.1，C-Kit，CD117，Proto-Oncogene Proteins c-kit，Mast/stem cell growth factor receptor Kit，PBT，Piebald trait protein，Tyrosine-protein kinase Kit，KIT Proto-Oncogene， Receptor Tyrosine Kinase，v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Approved Drugs	16
Drugs in Clinical Trials	31
Highest Development Stage	Approved

CD117 Product List

Product Category
Protein (15)
Product Status
Launched (15)
Species
Human (6)Mouse (2)Rhesus macaque (1)Cynomolgus (3)Canis (1)White-tufted-ear marmoset (1)Guinea pig (1)
Tag
His Tag (8)Fc Tag (4)His Tag & Avi Tag (3)
Conjugate
Unconjugated (10)Biotin-labeled (3)APC Labeled (1)PE Labeled (1)

Cat. No.	Species	Host	Product Description	Order Now
HOT CD7-H5255	Human	HEK293	Human CD117 / c-kit Protein, Fc Tag (MALS verified)	Add to Cart
HOT CD7-H52H4	Human	HEK293	Human CD117 / c-kit Protein, His Tag, low endotoxin (MALS verified)	Add to Cart
HOT CD7-H82E6	Human	HEK293	Biotinylated Human CD117 / c-kit Protein, His,Avitag™ (MALS verified)	Add to Cart
HOT CD7-M5259	Mouse	HEK293	Mouse CD117 / c-kit Protein, Fc Tag (MALS verified)	Add to Cart
HOT CD7-C52H9	Cynomolgus	HEK293	Cynomolgus CD117 / c-kit Protein, His Tag, low endotoxin (MALS verified)	Add to Cart
CD7-H525b	Human	HEK293	Human CD117 / c-kit Protein, Fc Tag (MALS verified)	Add to Cart
CD7-HA2H7	Human	HEK293	APC-Labeled Human CD117 Protein, His Tag	Add to Cart
CD7-HP2H9	Human	HEK293	PE-Labeled Human CD117 Protein, His Tag	Add to Cart
CD7-M82E3	Mouse	HEK293	Biotinylated Mouse CD117 / c-kit Protein, His,Avitag™ (MALS verified)	Add to Cart
CD7-C52H3	Canis	HEK293	Canis CD117 / c-kit Protein, His Tag (MALS verified)	Add to Cart

Total: 15

CD117 Background

Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

CD117 Synonyms

CD117,SCFR,c-Kit,KIT

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Barzolvolimab	CDX-0159	Phase 3 Clinical	Yale University, University Of Toronto - St. George Campus	Chronic Urticaria; Prurigo Nodularis; Skin Diseases; Eosinophilic Esophagitis; Urticaria; Dermatitis, Atopic	Details
Seralutinib	GB-002; PK-10571	Phase 3 Clinical	Gilead Sciences Inc	Pulmonary Arterial Hypertension	Details
Chiauranib	CS-2164; CS2164	Phase 3 Clinical	Shenzhen Chipscreen Biosciences Co Ltd	Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Pancreatic Ductal; Carcinoma, Hepatocellular	Details
Bezuclastinib	PLX-9486; CGT-9486	Phase 3 Clinical	Daiichi Sankyo Co Ltd	Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors; Neoplasm Metastasis; Mastocytosis	Details
oral enteric coated imatinib (Tenax Therapeutics)	TNX-201 (Tenax Therapeutics)	Phase 3 Clinical	PH Precision Med	Pulmonary Arterial Hypertension	Details
Sitravatinib	MGCD-516; IND-155305; MGCD-0516; MG-91516; MG-516	Phase 3 Clinical	Mirati Therapeutics Inc	Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Mouth Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Hepatic Insufficiency; Ureteral Neoplasms; Solid tumours; Lung Diseases; Liposarcoma; Uveal melanoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Carcinoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Kidney Neoplasms; Biliary Tract Neoplasms	Details
Elenestinib	BLU-263	Phase 3 Clinical	Blueprint Medicines Corp	Mastocytosis, Systemic; Mastocytosis	Details
Autologous Human C-Kit Cardiac Stem Cells (CSCs) II (ISCI / University of Miami Miller School of Medicine)		Phase 2 Clinical	University Of Miami, Elpiscience (Shanghai) Biopharma Ltd	Myocardial Infarction; Ventricular Dysfunction, Left	Details
Telatinib	EOC-315; BAY-57-9352	Phase 2 Clinical	Bayer AG	Solid tumours; Stomach Neoplasms	Details
Briquilimab	AMG-191; JSP-191; JSP191	Phase 2 Clinical	Amgen Inc, National Heart, Lung And Blood Institute, Stanford University	Myelodysplastic Syndromes; Chronic Urticaria; Severe Combined Immunodeficiency; Asthma; Leukemia, Myeloid, Acute; Granulomatous Disease, Chronic; Immunologic Deficiency Syndromes; Anemia, Sickle Cell	Details
DCC-3009	DCC-3009	Phase 2 Clinical	Deciphera Pharmaceuticals Inc	Gastrointestinal Stromal Tumors	Details
Sorafenib Tosylate/Comekibart	MG-D-1609	Phase 2 Clinical	Metagone Biotech Inc	Solid tumours	Details
Opelkibart elmanitin	MGTA-117	Phase 2 Clinical	Heidelberg Pharma AG	Myelodysplastic Syndromes; Leukemia, Myeloid, Acute	Details
18F-Dasatinib	18F-SKI-249380; [18F]-Fluoro-BMS-354825; [18F]Dasatinib; [18F]SKI-249380; [18F]Fluoro-BMS-354825	Phase 1 Clinical	Memorial Sloan Kettering Cancer Center	Bone Marrow Neoplasms; Carcinoma; Neoplasms; Sarcoma; Lymphoma; Diagnostic agents; Melanoma	Details
Tafetinib Malate	SIM-0702; SIM-1005; SIM-010603	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd	Neoplasms	Details
DPH-001	DPH-001; DPH001	Phase 1 Clinical	Disruptive Pharma AB		Details
QBH-196	QBH-196	Phase 1 Clinical	Shenyang Pharmaceutical University	Solid tumours; Stomach Neoplasms	Details
ETN-101	ETN101; ETN-101; MBP-11901	Phase 1 Clinical	Etnova Therapeutics Corp	Liver Neoplasms; Carcinoma, Hepatocellular	Details
CSCJC-3456	CSCJC3456; CSCJC-3456	Phase 1 Clinical	Changshan ConjuChem BioPharmaceutical Research and Development (Hebei) Co Ltd, Hebei Changshan Biochemical Pharmaceutical Co Ltd	Solid tumours	Details
THB-335	THB-335; THB335	Phase 1 Clinical	Third Harmonic Bio	Inflammation	Details
CDX-622	CDX-622	Phase 1 Clinical	Celldex Therapeutics Inc	Fibrosis; Inflammation; Hypersensitivity	Details
QX-013N	QX-013-N; QX013N	Phase 1 Clinical	Qyuns Therapeutics Co Ltd	Chronic Urticaria; Urticaria	Details
NN-2101	NN-2101	Phase 1 Clinical	Novelty Nobility Inc	Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion	Details
NN-3201	NN-3201	Phase 1 Clinical	Novelty Nobility Inc	Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Adenoid Cystic; Uveal melanoma; Neuroendocrine Tumors; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute	Details
THB-001	THB-001	Phase 1 Clinical	Novartis Corp	Gastrointestinal Diseases; Chronic Urticaria; Respiratory Tract Diseases	Details
T-1301	T-1301; DBPR-216	Phase 1 Clinical	Taivex Therapeutics Corp	Solid tumours; Lymphoma	Details
GS-0174	GS-0174	Phase 1 Clinical	Forty Seven Inc	Hematologic Neoplasms	Details
TR-64	TR-64	Phase 1 Clinical	Tarapeutics Science Inc	Solid tumours; Gastrointestinal Stromal Tumors	Details
AZD-3229	NB-003; NB003; AZD-3229; AZD3229	Phase 1 Clinical	Astrazeneca Turkey	Solid tumours; Gastrointestinal Stromal Tumors; Influenza B virus infection	Details
AGX-0073	AGX-0073	Phase 1 Clinical	Shanghai Aojian Biological Technology Co Ltd	Solid tumours	Details
Sorafenib tosylate (Bio-Synectics)	BS-104	Clinical	Bio-Synectics Inc		Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Anlotinib Dihydrochloride	AL-3818	Approved	Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	福可维	Mainland China	Carcinoma, Non-Small-Cell Lung	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	2018-05-08	Sarcoma, Alveolar Soft Part; Peritoneal Neoplasms; Colorectal Neoplasms; Urologic Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Bone Neoplasms; Endometrial Neoplasms; Gallbladder Neoplasms; Fallopian Tube Neoplasms; Thyroid Neoplasms; Medullary thyroid cancer (MTC); Glioma; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Melanoma; Osteoma; Gastroenteropancreatic neuroendocrine tumor; Small Cell Lung Carcinoma; Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Leiomyosarcoma; Esophageal Neoplasms; Stomach Neoplasms; Thoracic Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Biliary Tract Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Neuroendocrine Tumors; Sarcoma, Synovial; Lung Diseases, Interstitial; Liver Diseases; Sarcoma; Bile Duct Diseases; Nasopharyngeal Carcinoma	Details
Imatinib mesylate	CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201	Approved	Novartis Pharma Ag	glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec	EU	Leukemia, Myelogenous, Chronic	Novartis Europharm Ltd	2001-05-10	Diabetes Mellitus, Type 1; Hypereosinophilic Syndrome; Leukemia; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Ovarian Neoplasms; Solid tumours; Hypertension, Pulmonary; Hematopoietic stem cell transplantation (HSCT); Neoplasm, Residual; Skin Melanoma; Hematologic Neoplasms; Genital Diseases, Male; Ovarian germ cell tumor; Fibrosarcoma; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myeloid, Accelerated Phase; Loiasis; Rhinitis, Allergic, Seasonal; Polycythemia Vera; Genital Neoplasms, Male; Abdominal Neoplasms; Leukemia, Hairy Cell; Histiocytoma, Malignant Fibrous; Desmoplastic Small Round Cell Tumor; Rectal Neoplasms; Stomach Neoplasms; Myeloproliferative Disorders; Skin Neoplasms; Leukemia, Myelomonocytic, Chronic; Coronavirus Disease 2019 (COVID-19); Scleroderma, Systemic; Dermatofibrosarcoma; Liver Cirrhosis; Neoplasms; Neurofibromatoses; Graft vs Host Disease; Mastocytosis, Systemic; Idiopathic Pulmonary Fibrosis; Myelodysplastic Syndromes; Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma	Details
Lenvatinib Mesylate	MK-7902; ER-203492-00; E-7080	Approved	Eisai Co Ltd	Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛	United States	Thyroid Neoplasms	Eisai Inc	2015-02-13	Neuroendocrine Tumors; Paraganglioma; Thyroid Cancer, Papillary; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Glioma; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Breast Neoplasms; Cholangiocarcinoma; Osteosarcoma; Solid tumours; Carcinoma, Adenoid Cystic; Adenocarcinoma, Follicular; Liver Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Neoplasms; Renal Insufficiency; Pheochromocytoma; Esophageal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Liver Neoplasms; Biliary Tract Neoplasms	Details
Regorafenib	DAST; BAY-73-4506	Approved	Bayer AG	Stivarga, Resihance	United States	Colorectal Neoplasms	Bayer Healthcare Pharmaceuticals Inc	2012-09-27	Leukemia, Myeloid, Acute; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Esophageal adenocarcinoma; Lung Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Osteosarcoma; Thymoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Adenocarcinoma; Somatostatinoma; Gastrointestinal Neoplasms; Melanoma; Meningioma; Neoplasms; Solid tumours; Liver Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Carcinoma, Islet Cell; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Gastrinoma; Sarcoma	Details
Avapritinib	BLU-285; CS-3007	Approved	Blueprint Medicines Corp	Ayvakit, Ayvakyt, 泰吉华, Taijihua	United States	Gastrointestinal Stromal Tumors	Blueprint Medicines Corp	2020-01-09	Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma	Details
Vorolanib	CM-082; X-82; EYP-1901	Approved	Tyrogenex Inc	伏美纳, DURAVYU™	Mainland China	Carcinoma, Renal Cell	Betta Pharmaceuticals Co Ltd	2023-06-07	Diabetic macular oedema; Melanoma; Carcinoma, Non-Small-Cell Lung; Diabetic Retinopathy; Macular Degeneration; Carcinoma, Hepatocellular; Choroidal Neovascularization; Adenocarcinoma; Eye Diseases; Leukemia, Myeloid, Acute; Retinal Degeneration; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms	Details
Ripretinib	DCC-2618	Approved	Deciphera Pharmaceuticals	Qinlock, 擎乐	United States	Gastrointestinal Stromal Tumors	Deciphera Pharmaceuticals Llc	2020-05-15	Mastocytosis, Systemic; Neoplasms; Gastrointestinal Stromal Tumors	Details
Olverembatinib	D-824; GZD-824; APG-1351; GIBH-824; HQP-1351	Approved	Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences	耐立克	Mainland China	Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase	Guangzhou Shunjian Biomedical Technology Co Ltd	2021-11-25	Leukemia; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Leukemia, Myeloid; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Gastrointestinal Stromal Tumors	Details
Ponatinib Hydrochloride	AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534	Approved	Ariad	Iclusig	United States	Leukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma	Ariad Pharmaceuticals Inc	2012-12-14	Precursor Cell Lymphoblastic Leukemia-Lymphoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Biphenotypic, Acute; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Common Bile Duct Neoplasms; Leukemia, Myeloid, Accelerated Phase; Blast Crisis; Leukemia, Myelomonocytic, Chronic; Glioblastoma; Small Cell Lung Carcinoma; Adenocarcinoma of Lung; Hematologic Neoplasms; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Solid tumours; Leukemia	Details
Sunitinib Malate	PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt	Approved	Pfizer Inc	Sutent, 索坦	United States	Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell	Cppi Cv	2006-01-26	Kidney Neoplasms; Skin Melanoma; Teratoma; Liver Neoplasms; Ovarian Neoplasms; Ependymoma; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Solid tumours; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic; Leiomyosarcoma; Lymphoma, B-Cell; HIV Infections; Fibrosarcoma; Intestinal Neoplasms; Fibromatosis, Aggressive; Leukemia; Lymphoma, B-Cell, Marginal Zone; Carcinoma, Renal Cell; Pheochromocytoma; Stomach Neoplasms; Abdominal Neoplasms; Pelvic Neoplasms; Polycythemia Vera; Thoracic Neoplasms; Esophageal Neoplasms; Carcinoma, Islet Cell; Carcinoma; Histiocytoma, Malignant Fibrous; Hemangioblastoma; Squamous Cell Carcinoma of Head and Neck; Leukemia, Hairy Cell; Nose Neoplasms; Hypopharyngeal Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic neuroendocrine tumors (pNET); Plasmacytoma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Lymphoma, Large-Cell, Immunoblastic; Myelodysplastic Syndromes; Carcinoma, Transitional Cell	Details
Dasatinib Hydrate	BMS-354825; XS-004; NSC-732517	Approved	Bristol-Myers Squibb Company	Spraysel, 施达赛, Dasynoc, Spricel, Sprycel	United States	Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic	Bristol-Myers Squibb Company	2006-06-28	Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic; Leukemia; Liver Neoplasms; Hematologic Neoplasms; Hypereosinophilic Syndrome; Solid tumours; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Bone metastases; Skin Melanoma; Rhabdomyosarcoma; Chondrosarcoma; Immunoproliferative Small Intestinal Disease; Ovarian Neoplasms; Leukemia, Myeloid; Cystadenocarcinoma; HIV Infections; Rectal Neoplasms; Polycythemia Vera; Leukemia, Lymphoid; Leukemia, Hairy Cell; Hormone-Resistant Prostate Neoplasms; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms; Neoplasms; Salivary Gland Neoplasms; Skin Neoplasms; Myelodysplastic Syndromes; Scleroderma, Systemic; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Small Cell Lung Carcinoma; Leukemia, Myelomonocytic, Chronic; Mastocytosis, Systemic; Leukemia-Lymphoma, Adult T-Cell; Hodgkin Disease; Carcinoma, Verrucous; Lymphoma, Large-Cell, Immunoblastic; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (C	Details
Pexidartinib	PLX-3397	Approved	Daiichi Sankyo Co Ltd	Turalio	United States	Giant Cell Tumor of Tendon Sheath	Daiichi Sankyo Inc	2019-08-02	Prostatic Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma; Metastatic breast cancer; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Neurofibroma, Plexiform; Neurofibrosarcoma; Giant Cell Tumors; Sarcoma; Giant Cell Tumor of Tendon Sheath; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Glioblastoma; Pancreatic Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Solid tumours	Details
Pazopanib Hydrochloride	GSK-786034; GW-786034B; SB-786034; GW-786034	Approved	Glaxosmithkline Plc, Novartis Pharma Ag	维全特, Armala, Votrient, Patorma	United States	Carcinoma, Renal Cell; Sarcoma	Novartis Pharma Ag	2009-10-19	Osteosarcoma; Germinoma; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Uterine Cervical Diseases; Genital Neoplasms, Female; Gliosarcoma; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Chondrosarcoma, Extraskeletal Myxoid; Lung Neoplasms; Nasopharyngeal Carcinoma; Medullary thyroid cancer (MTC); Brain Neoplasms; Urethral Neoplasms; Psoriasis; Gastrinoma; Neuroblastoma; Prostatic Neoplasms; Breast Neoplasms; Neoplasms, Germ Cell and Embryonal; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Neoplasm Metastasis; Breast Neoplasms, Male; Uterine Cervical Neoplasms; Endodermal Sinus Tumor; Paraganglioma; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Sarcoma; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Choriocarcinoma; Uterine Neoplasms; Lymphoma; Carcinoma, Neuroendocrine; Glioma; Carcinoma, Embryonal; Skin Melanoma; Neoplasms; Herpes Genitalis; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Insulinoma; Pheochromo	Details
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Neuroblastoma; Thyroid Neoplasms; Hepatic Insufficiency; Astrocytoma; Peritoneal Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Gliosarcoma; Urethral Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Cholangiocarcinoma; Neurofibroma, Plexiform; Brain Neoplasms; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Sarcoma; Osteosarcoma; Sarcoma, Alveolar Soft Part; Meningioma; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Paraganglioma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Prostatic Neoplasms; Glioma; Brain metastases; Endometrial Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Lymphoma; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Carcinoma, Renal Cell; Adenoma, Islet Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Renal Insufficiency; Hepatoblastoma; Pheochromocytoma; Carcinoid Tumor; Carcinoma, Merkel Cell; Rejection of liver transp	Details
Sorafenib Tosylate	NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085	Approved	Onyx Pharmaceuticals Inc	Nexavar, 多吉美	United States	Carcinoma, Renal Cell	Bayer Healthcare Pharmaceuticals Inc	2005-12-01	Liver Neoplasms; Leukemia, Myelogenous, Chronic; Leiomyosarcoma; Rhabdomyosarcoma; Solid tumours; Ovarian Neoplasms; Fibromatosis, Aggressive; Kidney Neoplasms; Leukemia, Myeloid; Head and Neck Neoplasms; Skin Melanoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Histiocytoma, Malignant Fibrous; Stomach Neoplasms; Rectal Neoplasms; Carcinoma, Islet Cell; Insulinoma; Esophageal Neoplasms; Vipoma; Hemangiosarcoma; Abdominal Neoplasms; Wilms Tumor; Hypertension, Portal; Thyroid Carcinoma, Anaplastic; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Lymphomatoid Granulomatosis; Carcinoma, Transitional Cell; Colonic Neoplasms; Salivary Gland Neoplasms; Lymphoma, Large B-Cell, Diffuse; Multiple Endocrine Neoplasia Type 2a; Lymphoma, Large-Cell, Immunoblastic; Leukemia-Lymphoma, Adu	Details
Midostaurin	PKC-412; PKC-412A; CGP-41231; CGP-41251	Approved	Novartis Pharma Ag	Rydapt	United States	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-Cell	Novartis Pharmaceuticals Corp	2017-04-28	Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis	Details

Product Reviews

V***l2022-06-25
0People Like
Human CD117 / c-kit Protein, His Tag, low endotoxin (MALS verified)
We used the c-Kit protein to immunizations projects we are carrying for our studies and they performed great. The delivery was also very fast and the purchasing process very easy. We also purchased several other antibodies and recombinant proteins that we are currently testing and they all have very good quality. I have not used directly the technical services because it was not necessary, as the website is very easy and informative, so I found the products we wanted with no problem.

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