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CD30

CD30

CD30 Overview

Molecule Name
Tumor necrosis factor receptor superfamily member 8
Synonyms
TNFRSF8,CD30,D1S166E,Ki-1
Drug Development Progress
Drugs in Clinical Trials25
Approved Drugs1
Highest Development StageApproved
Target Synonym
CD30，CD30L receptor，TNFRSF8，Lymphocyte activation antigen CD30，TNF Receptor Superfamily Member 8，D1S166E，Tumor Necrosis Factor Receptor Superfamily， Member 8，Cytokine Receptor CD30，CD30 Antigen，Ki-1，Ki-1 Antigen，Tumor Necrosis Factor Receptor Superfamily Member 8
Background
Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. TNFRSF-8 is expressed by activated, but not by resting, T and B cells. Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. CD30 is the receptor for TNFSF8/CD30L. CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

CD30 Product List

Species
  • Human（10）
  • Cynomolgus（1）
  • Mouse（1）
Tag
  • His Tag（6）
  • Fc Tag（3）
  • Fc Tag & Avi Tag（1）
  • His Tag & Avi Tag（1）
  • Llama IgG Fc Tag（1）
Host
  • HEK293（12）
Conjugate
  • Unconjugated（5）
  • Biotin-labeled（2）
  • FITC Labeled（2）
  • AF488 Labeled（1）
  • AF647 Labeled（1）
  • PE Labeled（1）
Grade
  • RUO（12）
Low Endotoxin
  • Yes（4）
  • No（8）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
CD30
HOTAvitag
CD0-H82E6
Biotinylated Human CD30 / TNFRSF8 Protein, Avitag™,His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISABLIFlow

$360.00

25ug
CD30
HOT
CD0-HP2E3
PE-Labeled Human CD30 / TNFRSF8 Protein, His Tag (Site-specific conjugation)
Human
HEK293
Flow

$360.00

25tests
CD30
HOT
CD0-H52H5
Human CD30 / TNFRSF8 Protein, His Tag, low endotoxin
Human
HEK293
SDS-PAGE
ELISA

$270.00

100ug
CD30
CD0-C52Ha
Cynomolgus CD30 / TNFRSF8 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$270.00

100ug
CD30
CD0-H5250
Human CD30 / TNFRSF8 Protein, Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$270.00

100ug
CD30
Avitag
CD0-H82F4
Biotinylated Human CD30 / TNFRSF8 Protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
CD30
CD0-HA2H7
Alexa Fluor™ 488-Labeled Human CD30 / TNFRSF8 Protein, His Tag (HPLC verified)
Human
HEK293
HPLCSDS-PAGE
Flow

$330.00

25ug
CD30
CD0-HA2H9
Alexa Fluor™ 647-Labeled Human CD30 / TNFRSF8 Protein, His Tag
Human
HEK293
SDS-PAGE
Flow

$330.00

25ug
CD30
CD0-HF250
FITC-Labeled Human CD30 / TNFRSF8 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISA

$330.00

25ug
CD30
CD0-HF2H4
FITC-Labeled Human CD30 / TNFRSF8 Protein, His Tag
Human
HEK293
SDS-PAGE
ELISAFlow

$330.00

25ug
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Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
AcimtamigAFM-13Phase 2 ClinicalThe University Of Texas MD Anderson Cancer Center
Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mycosis Fungoides
Details
ATLCAR.CD30 cells (UNC Lineberger Comprehensive Cancer Center)Phase 2 ClinicalUnc Lineberger Comprehensive Cancer Center
Hodgkin Disease; Immune System Diseases; Immunoproliferative Disorders; Lymphatic Diseases; Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphomatoid Papulosis; Lymphoproliferative Disorders; Mycosis Fungoides; Neoplasms; Neoplasms, Germ Cell and Embryonal; Sezary Syndrome
Details
Autologous CD30+ CAR T Cells therapy(New York Medical College)Phase 2 ClinicalNew York Medical College, University Of North Carolina At Chapel Hill
Hodgkin Disease
Details
Itezocabtagene autoleucelTT-11; TT11Phase 2 ClinicalTessa Therapeutics Ltd
Hodgkin Disease; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Primary mediastinal B cell lymphoma
Details
BRD-01BRD-01Phase 2 ClinicalWuhan BioRaid Biotechnology Co Ltd
Hematologic Neoplasms; Hodgkin Disease
Details
PRA-052PRA-052; MK-8690; PR-600Phase 2 ClinicalPrometheus Biosciences Inc
Colitis, Ulcerative
Details
HSP-CAR-30HSP-CAR-30Phase 2 ClinicalFundació Institut De Recerca De L
Hodgkin Disease; Lymphoma, T-Cell
Details
Anti-CD30 CAR T-cell therapy (General Hospital of the People's Liberation Army/Cellular Biomedicine)CAR30-NKT; CBM-C30.1; CD30ScFv-CD8-CD137-CD3zetaPhase 2 ClinicalPla General Hospital
Hodgkin Disease
Details
Anti-CD30 chimeric antigen receptor T cell therapy (Immune cell)Phase 1 ClinicalImmune Cell Inc
Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic
Details
CD30.CAR-EBVST cell therapy (Baylor College of Medicine)TT-11XPhase 1 ClinicalBaylor College Of Medicine, Tessa Therapeutics Ltd
Hodgkin Disease; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large B-Cell, Diffuse
Details
EBV-specific-CAR.CD30EBV-specific-CAR.CD30; CAR.CD30 EBV-specific-CTLsPhase 1 ClinicalBaylor College Of Medicine, Methodist Hospital System, Texas Children'S Hospital
Hodgkin Disease; Lymphoma, Non-Hodgkin
Details
Anti-CD30 CAR T-cell therapy (Wuhan Bio-Raid)Phase 1 ClinicalWuhan BioRaid Biotechnology Co Ltd
Angioimmunoblastic T-cell Lymphoma; Hematologic Neoplasms; Hodgkin Disease; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral
Details
B-0069 (Shanghai Pharmaceuticals Holding)F0002-ADC; B-006(SCP)Phase 1 ClinicalShanghai Pharmaceuticals Holding Co Ltd
Hematologic Neoplasms; Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral
Details
CD30.CARH-27721; CD30.CARPhase 1 ClinicalBaylor College Of Medicine
Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral
Details
CD30 CAR-T Cells therapy (Unicar-Therapy Bio-Medicine Technology)U29Phase 1 ClinicalShanghai Unicar-Therapy Bio-Medicine Technology Co Ltd
Lymphoma
Details
ATLCAR.CD30.CCR4Phase 1 ClinicalUnc Lineberger Comprehensive Cancer Center
Immune System Diseases; Immunoproliferative Disorders; Lymphatic Diseases; Lymphoma; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, T-Cell, Cutaneous; Lymphomatoid Papulosis; Lymphoproliferative Disorders; Mycosis Fungoides; Neoplasms; Sezary Syndrome
Details
Chimeric antigen receptor gene modified T cells therapy (Qilu Cell Therapy Engineering&Technology)Phase 1 ClinicalShandong Qilu Cell Treapy Engineering&Technology Co Ltd
Lymphoma; Lymphoma, B-Cell; Lymphoma, T-Cell
Details
Anti-CD20/CD30-CAR-T Cell therapy(Shanghai Tongji Hospital)Phase 1 ClinicalShanghai Tongji Hospital
Leukemia, B-Cell; Lymphoma; Lymphoma, B-Cell
Details
CD30-Targeted LCAR-HL30 Cells therapy(Legend Biotechnology)Phase 1 Clinical
Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic
Details
SGN-35CSGN-35C; PF-08046044Phase 1 ClinicalSeagen Inc
Hodgkin Disease; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral
Details
Anti-CD30 CAR T-cell therapyPhase 1 ClinicalMinghui (Nanjing) Gene Biotechnology Co Ltd
Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic
Details
CD30 biAb-AATC(The Medical College Of Wisconsin Nonprofit)Phase 1 ClinicalThe Medical College Of Wisconsin Nonprofit
Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous
Details
Anti-CD30 CAR-T cell therapy (National Cancer Institute)Hu30-CD28zPhase 1 ClinicalNational Cancer Institute
Enteropathy-Associated T-Cell Lymphoma; Lymphoma; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral
Details
SGN-CD30CSGN-CD30CPhase 1 ClinicalSeattle Genetics Inc
Lymphoma
Details
Anti-CD30 chimeric antigen receptor T cell therapy (Yake Biotechnology)ClinicalShanghai YaKe Biotechnology Co Ltd
Hodgkin Disease
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
Brentuximab vedotincAC10-vcMMAE; SGN-30; cAC10-Val-Cit-MMAE; cAC-10; SGD-1010; SGN-35ApprovedSeagen IncAdcetris, 安适利United StatesLymphoma, Large-Cell, Anaplastic; Hodgkin DiseaseSeagen Inc2011-08-19
Anemia, Refractory, with Excess of Blasts; Carcinoma; Enteropathy-Associated T-Cell Lymphoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Hidradenitis Suppurativa; HIV Infections; Hodgkin Disease; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphomatoid Papulosis; Mastocytosis, Systemic; Mesothelioma; Mycosis Fungoides; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Germ Cell and Embryonal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma, Kaposi; Scleroderma, Diffuse; Scleroderma, Systemic; Sezary Syndrome; Solid tumours
Details
Customer Reviews
  • R*** 2021-09-22
    FITC-Labeled Human CD30 / TNFRSF8 Protein, His Tag
    Our research group work with CAR-T therapy for the treatment of hematological malignancies, and use the Fitc-Labeled Human CD30 protein for detection of CAR30 cells in patients by flow cytometry. Our results are fantastic, because the observe consistency and a reproducible experiments by flow cytometry. The logistic speed is very effective and allows us to work always up to date with our projects.
  • 1***22020-01-10
    Human CD30 / TNFRSF8 Protein, Fc Tag, low endotoxin (MALS verified)
    There are many CD30 products, with various tags. What I chose was the hFc tag protein. I also purchased CD30L for Fortebio experiment. The result was pretty good.