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GDNF

GDNF

GDNF Overview

Molecule Name
Glial cell line-derived neurotrophic factors
Synonyms
GDNF,ATF
Drug Development Progress
Drugs in Clinical Trials5
Approved Drugs0
Highest Development StageNDA/BLA
Target Synonym
Glial Cell Line-Derived Neurotrophic Factors
Background
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

GDNF Product List

Species
  • Human（4）
  • Mouse（1）
Tag
  • Tag Free（4）
  • His Tag（1）
Host
  • E. coli（3）
  • HEK293（2）
Conjugate
  • Unconjugated（5）
Grade
  • PG (pre-GMP)（2）
  • RUO（2）
  • GMP（1）
Low Endotoxin
  • Yes（1）
  • No（4）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
GDNF
HOT
GMP-GDFH17
GMP Human GDNF Protein (E. coli)
Human
E. coli
MSSDS-PAGE
CELL BASE

$700.00

50ug
GDNF
GDF-H5118
Human GDNF / ATF / hGDNF Protein (E. coli), premium grade
Human
E. coli
SDS-PAGE
ELISACELL BASE

$270.00

20ug
GDNF
GDF-H5119
Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade
Human
E. coli
SDS-PAGE
ELISACELL BASE

$200.00

20ug
GDNF
GDF-H5219
Human GDNF / ATF / hGDNF Protein, premium grade
Human
HEK293
SDS-PAGE
ELISA

$245.00

20ug
GDNF
GDF-M5245
Mouse GDNF / ATF Protein, His Tag, low endotoxin (MALS verified)
Mouse
HEK293
MALSSDS-PAGE

$205.00

20ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
AB-1005AMT-140; AB-1005; AAV2-GDNF; AAV2-GDNF-MSA; AAV2-GDNF-PDPhase 2 ClinicalUc San Francisco
Multiple System Atrophy; Parkinson Disease
Details
NRO-1NRO-1; SI-01Phase 2 ClinicalSenju Pharmaceutical Co Ltd
Xerophthalmia
Details
Ifezuntirgene inilparvovecAAV5-miSNP15; AMT-130; AAV5-miHtt12; AAV5-miSNP7Phase 2 ClinicalAmsterdam Molecular Therapeutics, Uniqure
Huntington Disease
Details
AAV2-GDNF gene therapy (NINDS)Phase 1 ClinicalNational Institute Of Neurological Disorders And Stroke
Parkinson Disease
Details
RGL-193RGL-193Phase 1 ClinicalShanghai Regenelead Therapies Co Ltd
Parkinson Disease
Details
Customer Reviews
  • P***i2025-05-13
    Human GDNF / ATF / hGDNF Protein, premium grade
    Acro Biosystems' GDNF recombinant protein has proven to be a reliable and high-quality reagent for research focused on neuronal development and maturation. In my study involving cortical projection neuron cultures, GDNF consistently supported neuronal survival, neurite outgrowth, and the expression of maturation markers. Its batch-to-batch consistency and biological activity have made it an essential component in our differentiation protocols. I highly recommend this product to laboratories engaged in both fundamental neuroscience research and translational studies aiming to model neurodegenerative diseases or explore neuroprotective strategies.