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Gremlin

Gremlin Overview

English NameGremlin-1Approved Drugs0
Drugs in Clinical Trials2Target SynonymCell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
Highest Development StagePhase 2 Clinical
English NameGremlin-1
Target SynonymCell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

Gremlin Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    His Tag (1)Fc Tag (1)

  • Conjugate

    Unconjugated (2)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
GR1-H5254
Human
HEK293
Human Gremlin / GREM1 Protein, Fc Tag
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GR1-H52H3
Human
HEK293
Human Gremlin / GREM1 Protein, His Tag
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Total: 2
  • 1

Gremlin Background

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Gremlin Synonyms

GREM1,CKTSF1B1,DAND2,DRM,PIG2

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
TST-003TST-003Phase 2 ClinicalMabspace Biomedicine (Suzhou) Co LtdSolid tumours; Neoplasms; Colorectal Neoplasms; Neoplasm Metastasis
Details
GinisortamabUCB-6114Phase 2 ClinicalUcb Biopharma SrlSolid tumours
Details
  • Product List
  • Clinical Drug Information
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