GUCY2D

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GUCY2D Overview

Molecule Name

Retinal guanylyl cyclase 1

Synonyms

GUCY2D,Retinal guanylyl cyclase 1,RETGC-1,CORD6,GUC1A4,GUC2D,ROS-GC

Drug Development Progress

Drugs in Clinical Trials1

Approved Drugs0

Highest Development StagePhase 2 Clinical

Target Synonym

RETGC-1，CG-E，Guanylate cyclase 2D， retinal，Rod outer segment membrane guanylate cyclase (ROS-GC)，CORD6，GUC1A4，GUC2D，RETGC，RETGC1

Background

GUCY2D also known as CORD6, GUC1A4, GUC2D ROS-GC and RETGC-1, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.