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IL-17 RA & IL-17 RC

IL-17 RA & IL-17 RC

IL-17 RA & IL-17 RC Overview

Molecule Name
Interleukin-17 receptor A
Synonyms
IL-17 RA & IL-17 RC,IL-17RA & IL-17RC,CD217 & IL-17 RC
Drug Development Progress
Drugs in Clinical Trials2
Approved Drugs1
Highest Development StageApproved
Target Synonym
CDw217，IL-17 receptor A，IL17R，IL17RA，Interleukin 17 Receptor A，IL-17RA，Interleukin 17 Receptor，CD217 Antigen，HIL-17R，CANDF5，CD217，IMD51，Interleukin-17 receptor A
Background
Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.

IL-17 RA & IL-17 RC Product List

Species
  • Human（1）
Tag
  • Fc Tag（1）
Host
  • HEK293（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
IL-17 RA & IL-17 RC
ILC-H5257
Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRBLI

$415.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
XCUR-17XCUR-17Phase 1 ClinicalExicure Inc
Psoriasis
Details
PN-881PN-881Phase 1 ClinicalProtagonist Therapeutics Inc
Dermatitis; Psoriasis
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
BrodalumabAMG-827; KHK-4827; IL-17R mAb; MEDI-6365ApprovedAmgen IncSiliq, Lumicef, Kyntheum, 立美芙JapanPsoriasis; Arthritis, PsoriaticKyowa Kirin Co Ltd2016-07-04
Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Axial Spondyloarthritis; Brain Neoplasms; Breast Neoplasms; Colonic Neoplasms; Crohn Disease; Esophageal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Hidradenitis Suppurativa; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Mouth Neoplasms; Non-radiographic axial spondyloarthritis; Palmoplantar pustulosis; Pancreatic Neoplasms; Plaque psoriasis; Prostatic Neoplasms; Psoriasis; Pustular psoriasis; Rectal Neoplasms; Scleroderma, Systemic; Skin Neoplasms; Solid tumours; Spondylitis, Ankylosing; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms
Details
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