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IL-2 R beta

IL-2 R beta

IL-2 R beta Overview

Molecule Name
Interleukin-2 receptor beta chain
Synonyms
IL2RB,RP5-1170K4.6,CD122,P70-75
Drug Development Progress
Drugs in Clinical Trials15
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
IL2RB，IMD63，IL-2RB，p75，CD122，Interleukin 2 Receptor Subunit Beta，Interleukin-15 Receptor Subunit Beta，Interleukin 15 Receptor， Beta，Interleukin 2 Receptor， Beta，IL-2R Subunit Beta，CD122 Antigen，P70-75，IL15RB，High Affinity IL-2 Receptor Beta Subunit，Interleukin-2 Receptor beta Subunit，Interleukin-2 receptor subunit beta，IL-2 receptor subunit beta，High affinity IL-2 receptor subunit beta
Background
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

IL-2 R beta Product List

Species
  • Cynomolgus（3）
  • Human（3）
  • Mouse（2）
  • Canine（1）
Tag
  • His Tag（4）
  • Fc Tag（3）
  • His Tag & Avi Tag（2）
Host
  • HEK293（9）
Conjugate
  • Unconjugated（7）
  • Biotin-labeled（2）
Grade
  • RUO（9）
Low Endotoxin
  • Yes（2）
  • No（7）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
IL-2 R beta
HOT
CD2-H5221
Human IL-2 R beta / CD122 Protein, His Tag, low endotoxin (HPLC & SPR verified)
Human
HEK293
HPLCSDS-PAGE
SPRBLICELL BASE

$455.00

100ug
IL-2 R beta
HOT
ILA-M52H5
Mouse IL-2 R beta Protein, His Tag, low endotoxin
Mouse
HEK293
SDS-PAGE
SPR

$360.00

50ug
IL-2 R beta
HOT
ILB-C52H9
Cynomolgus IL-2 R beta / CD122 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
SPR

$360.00

50ug
IL-2 R beta
HOTAvitag
ILB-H82E3
Biotinylated Human IL-2 R beta / CD122 Protein, His,Avitag™ (BLI verified)
Human
HEK293
SDS-PAGE
ELISABLI

$375.00

25ug
IL-2 R beta
ILA-C5253
Cynomolgus IL-2 R beta Protein, Fc Tag
Cynomolgus
HEK293
SDS-PAGE
ELISA

$350.00

50ug
IL-2 R beta
ILA-C52H5
Canine IL-2 R beta Protein, His Tag
Canine
HEK293
SDS-PAGE

$360.00

50ug
IL-2 R beta
Avitag
ILA-C82E3
Biotinylated Cynomolgus IL-2 R beta Protein, His,Avitag™ (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$350.00

25ug
IL-2 R beta
ILB-H5253
Human IL-2 R beta / CD122 Protein, Fc Tag (MALS & SPR verified)
Human
HEK293
MALSSDS-PAGE
ELISASPR

$360.00

50ug
IL-2 R beta
ILB-M5253
Mouse IL-2 R beta / CD122 Protein, Fc Tag
Mouse
HEK293
SDS-PAGE
SPR

$360.00

50ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
BempegaldesleukinBMS-986321; ONO-7911; NKTR-214Phase 3 ClinicalNektar Therapeutics
Brain Neoplasms; Carcinoma, Renal Cell; Coronavirus Disease 2019 (COVID-19); Ependymoma; Glioma; Head and Neck Neoplasms; Leukemia; Lymphoma; Medulloblastoma; Melanoma; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms
Details
AWT-020AWT020; AWT-020; JS213; JS-213Phase 2 ClinicalAnwita Biosciences Inc
Autoimmune Diseases of the Nervous System; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Neoplasms; Solid tumours
Details
GI-101SIM-323; SIM323; SIM0323; GI-101Phase 2 ClinicalGI Innovation Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Neoplasms; Solid tumours; Uterine Cervical Neoplasms
Details
MB-501MB501; MB-501Phase 2 ClinicalAscendis Pharma Inc
Neoplasms
Details
PegenzileukinIBI-127; THOR-707; SAR-444245Phase 2 ClinicalSynthorx Inc
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Hodgkin Disease; Intestinal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Melanoma; Mesothelioma; Multiple Myeloma; Neoplasm Metastasis; Oropharyngeal Neoplasms; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms
Details
IPH-6501IPH-6501; IPH-65Phase 2 ClinicalInnate Pharma SA
Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms
Details
LTC-004LTC004; LTC-004Phase 2 ClinicalLeto Laboratories Co Ltd
Colorectal Neoplasms; Neoplasms; Pancreatic Neoplasms; Sarcoma; Solid tumours
Details
FB-102FB-102; FB102Phase 2 ClinicalForte Biosciences Inc
Alopecia Areata; Celiac Disease; Graft vs Host Disease; Malabsorption Syndromes; Vitiligo
Details
TransCon IL-2 β/γPhase 2 ClinicalAscendis Pharma A/S
Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Ovarian Neoplasms; Solid tumours
Details
MDNA-11MDNA-11; MDNA11Phase 2 ClinicalMedicenna Therapeutics Corp
Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Melanoma; Mesothelioma; Microsatellite Instability; Microsatellite instability-high cancer; Mismatch Repair Deficient Cancer; Ovarian Neoplasms; Peritoneal Neoplasms; Skin Melanoma; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
Simlukafusp alfaFAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FPPhase 1 ClinicalF. Hoffmann-La Roche Ltd
Breast Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Head and Neck Neoplasms; Melanoma; Solid tumours; Uterine Cervical Neoplasms
Details
BJ-001(Boji Biomedical Technology)BJ-001Phase 1 ClinicalBoji Biomedical Technology (Hangzhou) Co Ltd
Communicable Diseases; Neoplasm Metastasis; Solid tumours
Details
STK-009STK-009Phase 1 ClinicalSynthekine Inc
Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Scleroderma, Systemic
Details
NL-201 (Neoleukin Therapeutics)NL-201Phase 1 ClinicalNeoleukin Therapeutics Inc
Solid tumours
Details
Recombinant human interleukin 15(Beijing Kawin)Phase 1 ClinicalBeijing Kawin Technology Share-Holding Co Ltd
Solid tumours
Details
Customer Reviews
  • V***n2025-02-11
    Human IL-2 R beta / CD122 Protein, His Tag, low endotoxin (HPLC & SPR verified)
    I bought this Human recombinant IL-2 R β / CD122 protein to test some anti-CD122 antibodies using ELISA assays where I coat the plate with the CD122 protein. I observed the expected affinity (Kd) results for my antibody (0.3 µg/mL), and I also observed the same results whether I used the CD122 protein freshly reconstituted or freeze-thawed once, showing that this is a really robust purified protein! Lastly, I compared coating my ELISA plates with varying concentrations of CD122 protein (0.25 - 8 µg/mL), finding that I could coat my plates with very little proteins and still observed consistent affinity measurements. This product is a really robust! I will definitely be buying products from Acro Biosystems in the future.