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IL-4

IL-4

IL-4 Overview

Molecule Name
Interleukin-4
Synonyms
IL4,BCGF1,BSF1
Drug Development Progress
Drugs in Clinical Trials14
Approved Drugs2
Highest Development StageApproved
Target Synonym
MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4
Background
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

IL-4 Product List

Species
  • Human（6）
  • Cynomolgus（3）
  • Mouse（2）
  • Rabbit（1）
Tag
  • His Tag（4）
  • His Tag & Avi Tag（3）
  • Tag Free（3）
  • Fc Tag（2）
Host
  • HEK293（12）
Conjugate
  • Unconjugated（9）
  • Biotin-labeled（3）
Grade
  • RUO（10）
  • GMP（1）
  • PG (pre-GMP)（1）
Low Endotoxin
  • Yes（2）
  • No（10）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
IL-4
HOT
IL4-H5253
Human IL-4 Protein, Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$415.00

100ug
IL-4
HOT
IL4-H52H9
Human IL-4 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$415.00

100ug
IL-4
HOT
IL4-H4218
Human IL-4 Protein, premium grade
Human
HEK293
HPLCSDS-PAGE
ELISACELL BASE

$215.00

20ug
IL-4
HOTAvitag
IL4-H82E0
Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISACELL BASE

$415.00

25ug
IL-4
HOT
GMP-L04H26
GMP Human IL-4 Protein
Human
HEK293
SDS-PAGE
CELL BASE

$830.00

50ug
IL-4
IL4-C5259
Cynomolgus IL-4 Protein, Fc Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$395.00

100ug
IL-4
IL4-C52H9
Cynomolgus IL-4 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISASPR

$360.00

100ug
IL-4
Avitag
IL4-C82E3
Biotinylated Cynomolgus IL-4 Protein, His,Avitag™ (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
IL-4
IL4-H5219
Human IL-4 Protein, Research Grade
Human
HEK293
HPLCSDS-PAGE
ELISACELL BASE

$189.00

20ug
IL-4
IL4-M52H5
Mouse IL-4 Protein, His Tag
Mouse
HEK293
SDS-PAGE
ELISA

$395.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Dupilumab biosimilar (Jingxing Pharmaceutical)GS101; GS-101; GS-101 (Jingxing Pharmaceutical)Phase 3 ClinicalJiangsu Jingxing Pharmaceutical Technology Co Ltd
Dermatitis, Atopic
Details
Dupilumab biosimilar (Qilu Pharma)QL2108; QL-2108Phase 3 ClinicalQilu Pharmaceutical Co Ltd
Asthma; Dermatitis, Atopic; Prurigo
Details
TilrekimigPF-07275315Phase 3 ClinicalPfizer Inc
Asthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive
Details
EblasakimabMK-6105; ASLAN-004; CSL-334Phase 2 ClinicalCsl Ltd, Merck Sharp & Dohme Corp
Dermatitis, Atopic; Hypersensitivity
Details
Dectrekumab/VAK-694QBX-258Phase 2 ClinicalNovartis Pharma Ag
Asthma; Lymphedema
Details
OCH-NCNP1OCH-NCNP1Phase 2 ClinicalKeio University
Crohn Disease; Multiple Sclerosis
Details
OmpekimigPF-07264660Phase 2 ClinicalPfizer Inc
Dermatitis, Atopic
Details
AUP1602-CAUP-16; AUP1602-CPhase 2 ClinicalAurealis
Diabetic Foot; Ulcer
Details
Dupixent biosimilar (Chong Kun Dang Pharmaceutical)CKD-706Phase 1 ClinicalChong Kun Dang Pharmaceutical Corp
Dermatitis, Atopic
Details
Dupilumab biosimilar (China Resources Biopharma)Phase 1 ClinicalChina Resources Biopharmaceutical Co Ltd
Dermatitis, Atopic
Details
Dupilumab biosimilar (Jiangsu Jingxing Pharma)Phase 1 ClinicalJiangsu Jingxing Pharmaceutical Technology Co Ltd
Dermatitis, Atopic
Details
Dupilumab biosimilar (Chengdu Kanghong)KH-816; KH816Phase 1 ClinicalChengdu Kanghong Biotechnologies Co Ltd
Dermatitis, Atopic
Details
Dupilumab biosimilar (Jushi Biopharma)Phase 1 ClinicalJushi Biopharmaceutical Co Ltd
Dermatitis, Atopic
Details
Dupilumab biosimilar (Bio-Thera Solutions)BAT2406; BAT-2406Phase 1 ClinicalBio-Thera Solutions Ltd
Asthma; Dermatitis, Atopic; Eosinophilic Esophagitis; Nasal Polyps; Prurigo Nodularis; Sinusitis
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
DupilumabREGN-668; SAR-231893ApprovedRegeneron Pharmaceuticals Inc, SanofiDupixent, 达必妥United StatesDermatitis, AtopicRegeneron Pharmaceuticals Inc2017-03-28
Allergic Fungal Rhinosinusitis; Alopecia Areata; Angioedema; Aspergillosis, Allergic Bronchopulmonary; Asthma; Asthma, Aspirin-Induced; Chronic Urticaria; Colitis, Ulcerative; Conjunctivitis, Allergic; Coronavirus Disease 2019 (COVID-19); Dermatitis; Dermatitis, Atopic; Eczema; Eosinophilic Esophagitis; Eosinophilic gastroenteritis (EG); Genetic Diseases, Inborn; Hypereosinophilic Syndrome; Hypersensitivity; Hypersensitivity, Immediate; Keloid; Keratoconjunctivitis; Lichenoid Eruptions; Milk Hypersensitivity; Nasal Polyps; Nephrotic Syndrome; Neurodermatitis; Paranasal Sinus Diseases; Peanut Hypersensitivity; Pemphigoid, Bullous; Prostatic Neoplasms; Prurigo; Prurigo Nodularis; Pruritus; Pulmonary Disease, Chronic Obstructive; Respiration Disorders; Respiratory Sounds; Respiratory Tract Diseases; Rhinitis, Allergic; Scleroderma, Localized; Sinusitis; Skin Diseases; Skin Diseases, Eczematous; Sleep Apnea Syndromes; Urticaria
Details
Berdazimer sodiumNVN-1000-SB-206-Novan; SB-206; MAP3-NONOate - SB-206; NVN1000-SB206; SB-019; NI-MC101; SB-207; SB-208; SB-204; SB-414ApprovedUniversity Of North Carolina At Chapel HillKINSOLUSTM, Zelsuvmi, ZELSUVMIUnited StatesMolluscum ContagiosumLnhc Inc2024-01-05
Acne Vulgaris; Condylomata Acuminata; Dermatitis, Atopic; Molluscum Contagiosum; Psoriasis; Tinea Pedis
Details
Customer Reviews
  • M***e2023-06-15
    IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit
    We have used this kit to profile compounds. This kit is both reliable and easy to use, and it shipped quickly. The 96 test kit is also amenable to scaling to a 384 well format for additional screening capabilities. In our experience, the customer service at ACRO has always been prompt when inquiring about when items will be restocked and when they have shipped.