Integrin α4β7 Proteins, Cell Lines & ELISA Kits

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Integrin alpha 4 beta 7 Overview

Molecule Name

Integrin alpha-4/beta-7

Synonyms

Integrin alpha 4 beta 7,ITGA4&ITGB7

Drug Development Progress

Drugs in Clinical Trials14

Approved Drugs4

Highest Development StageApproved

Target Synonym

LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1

Background

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Integrin alpha 4 beta 7 Product List

Molecule	Cat. No.	Product Name	Species	Host	Purity	Activity	Size&Price
Integrin alpha 4 beta 7	IT7-C52W4	Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	Cynomolgus	HEK293	MALSSDS-PAGE	ELISASPR	$475.00 100ug
Integrin alpha 4 beta 7	Avitag IT7-C82W3	Biotinylated Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Cynomolgus	HEK293	MALSSDS-PAGE	ELISA	$160.00 25ug
Integrin alpha 4 beta 7	IT7-H52W4	Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified)	Human	HEK293	MALSSDS-PAGE	ELISASPR	$535.00 100ug
Integrin alpha 4 beta 7	Avitag IT7-H82W4	Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	Human	HEK293	MALSSDS-PAGE	ELISA	$415.00 25ug

Integrin alpha 4 beta 7 >

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cat. No. IT7-C52W4

Species

Cynomolgus

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$475.00

Integrin alpha 4 beta 7 >

Avitag

Biotinylated Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT7-C82W3

Species

Cynomolgus

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$160.00

Integrin alpha 4 beta 7 >

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified)

Cat. No. IT7-H52W4

Species

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISASPR

$535.00

Integrin alpha 4 beta 7 >

Avitag

Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Cat. No. IT7-H82W4

Species

Human

Host

HEK293

Purity

MALSSDS-PAGE

Activity

ELISA

$415.00

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FAQ

How can I distinguish a TSLP-binding antibody from a receptor-blocking antibody?

Confirm TSLP binding by ELISA, SPR, or BLI, then test inhibition of the TSLP–TSLPR–IL-7Rα interaction. Strong binding with weak inhibition suggests a non-blocking epitope or an unfavorable binding geometry.

Why should TSLP blockers be tested against receptor-complex assembly rather than TSLP–TSLPR binding alone?

TSLP first engages TSLPR and then recruits IL-7Rα to form the signaling complex. Pairwise binding identifies direct interaction, while a TSLP/TSLPR/IL-7Rα inhibition assay tests whether the candidate disrupts complex assembly.

When should wild-type TSLP or the R127A/R130A variant be used?

R127A/R130A removes a putative furin-cleavage site and can improve stability of the full-length protein. It is useful for reproducible binding assays, while wild-type TSLP is preferable when native sequence fidelity is the primary requirement.

How should species selection be planned for TfR1-targeted delivery programs?

Use human TfR1 for immunization and primary screening, then compare cynomolgus, mouse, or rat TfR1 according to the planned model. Matched construct and capture formats are essential for interpreting cross-species affinity.

Which TfR1 format helps minimize avidity bias in affinity measurements?

Tag-free or His-tagged TfR1 is generally preferred when measuring monovalent kinetics. Fc-fused TfR1 can improve stability or capture but may introduce dimerization-related avidity, so results should be confirmed with a second format.

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Resources

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Etrolizumab	PRO-145223; rhuMAb-Beta7; R-7413; RG-7413	Phase 3 Clinical	Genentech Inc	Colitis, Ulcerative; Crohn Disease	Details
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	Details
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	Details
Natalizumab biosimilar (GENERIUM Pharmaceuticals)	GNR-093	Phase 3 Clinical	Generium Pharmaceuticals	Multiple Sclerosis	Details
LY-4268989	MORF-057; LY-4268989; LY4268989	Phase 2 Clinical	Morphic Therapeutic Inc	Colitis, Ulcerative; Crohn Disease	Details
EA-1080	EA-1080; NSHO-101	Phase 2 Clinical	Ea Pharma	Colitis, Ulcerative; Crohn Disease; Inflammatory Bowel Diseases	Details
PN-10943	PN-10943-A; PN-10943; PN-943	Phase 2 Clinical	Protagonist Therapeutics Inc	Colitis, Ulcerative	Details
Emvistegrast	GS-1427	Phase 2 Clinical	Gilead Sciences Sl	Colitis, Ulcerative; Inflammatory Bowel Diseases	Details
ABBV-466		Phase 2 Clinical	Abbvie Inc	Crohn Disease	Details
SPY-001	SPY001; SPY-001; PR-011; PR011; SPY001-001	Phase 2 Clinical	Paragon Therapeutics Inc	Colitis; Colitis, Ulcerative; Inflammatory Bowel Diseases	Details
Trosunilimab	ABBV-382	Phase 2 Clinical	Abbvie Inc	Crohn Disease; HIV Infections	Details
PTG-100	PTG-100	Phase 1 Clinical	Protagonist Therapeutics Inc	Celiac Disease; Colitis, Ulcerative	Details
NSHO-102	NSHO-102	Phase 1 Clinical	Ensho Therapeutics Inc	Inflammatory Bowel Diseases	Details
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indication	Clinical Trial
Carotegrast methyl	AJM-300	Approved	Ea Pharma, Eisai Co Ltd	Carogra	Japan	Colitis, Ulcerative	Ea Pharma Co Ltd	2022-03-28	Colitis, Ulcerative	Details
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	Details
Natalizumab biosimilar (Polpharma Biologics)	PB-006; DST-356A1	Approved	Polpharma Biologics Sa	Tyruko	United States	Multiple Sclerosis; Crohn Disease	Sandoz Inc	2023-08-24	Crohn Disease; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting	Details
Natalizumab	BG-0002; TY-21.6; AN-10022; BG-00002; AN-100226; BG-0002-E	Approved	Biogen Inc, Perrigo Llc	Tysabri, Antegran, Antegren	United States	Crohn Disease; Multiple Sclerosis	Biogen Idec	2004-11-23	Arthritis, Rheumatoid; Crohn Disease; Demyelinating Diseases; Epilepsies, Partial; Graft vs Host Disease; Ischemic Stroke; Multiple Myeloma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myositis, Inclusion Body	Details

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Can’t find what you need?

How can I distinguish a TSLP-binding antibody from a receptor-blocking antibody?

Why should TSLP blockers be tested against receptor-complex assembly rather than TSLP–TSLPR binding alone?

When should wild-type TSLP or the R127A/R130A variant be used?

How should species selection be planned for TfR1-targeted delivery programs?

Which TfR1 format helps minimize avidity bias in affinity measurements?

Clinical Drug Information

Marketed Drug Information