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Osteoactivin

Osteoactivin

Osteoactivin Overview

Molecule Name
Transmembrane glycoprotein NMB
Synonyms
GPNMB,HGFIN,NMB,Osteoactivin
Drug Development Progress
Drugs in Clinical Trials2
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Background
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin Product List

Species
  • Human（1）
Tag
  • His Tag（1）
Host
  • HEK293（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • Yes（1）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
Osteoactivin
GPB-H5229
Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin
Human
HEK293
SDS-PAGE

$340.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Glembatumumab vedotinCR-011; CDX-011; CR-011-ADC; CR011-vcMMAEPhase 2 ClinicalCelldex Therapeutics
Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Osteosarcoma; Skin Melanoma; Solid tumours; Triple Negative Breast Neoplasms; Uveal melanoma
Details
GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta)GCAR1Phase 1 ClinicalAHS Cancer Control Alberta
Carcinoma, Renal Cell; Sarcoma; Sarcoma, Alveolar Soft Part; Triple Negative Breast Neoplasms
Details
Customer Reviews
  • A***c2026-02-27
    Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin
    The Human Osteoactivin / GPNMB Protein, His Tag I purchased has been a reliable and useful reagent for interference testing. This reagent was optimal for work in both a PK and ADA assay. There have been no observed lot to lot differences, which is important in my line of work. I would recommend this product.