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Siglec-15

Siglec-15

Siglec-15 Overview

Molecule Name
Sialic acid-binding Ig-like lectin 15
Synonyms
CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15
Drug Development Progress
Drugs in Clinical Trials3
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15
Background
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15 Product List

Species
  • Human（4）
  • Mouse（1）
  • Rat（1）
  • Rhesus macaque（1）
Tag
  • His Tag（4）
  • Fc Tag（1）
  • Fc Tag & Avi Tag（1）
  • His Tag & Avi Tag（1）
Host
  • HEK293（7）
Conjugate
  • Unconjugated（5）
  • Biotin-labeled（2）
Grade
  • RUO（7）
Low Endotoxin
  • Yes（1）
  • No（6）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
Siglec-15
HOT
SG5-H52H3
Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$415.00

100ug
Siglec-15
HOTAvitag
SG5-H82F5
Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag™
Human
HEK293
SDS-PAGE
ELISABLICELL BASE

$360.00

25ug
Siglec-15
HOT
SG5-H5253
Human Siglec-15 / CD33L3 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISASPRBLICELL BASE

$415.00

100ug
Siglec-15
HOTAvitag
SG5-H82E9
Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag™ (recommended for biopanning)
Human
HEK293
SDS-PAGE
ELISA

$360.00

25ug
Siglec-15
SG5-C52H6
Rhesus macaque Siglec-15 / CD33L3 Protein, His Tag
Rhesus macaque
HEK293
SDS-PAGE
ELISA

$360.00

100ug
Siglec-15
SG5-M52H7
Mouse Siglec-15 / CD33L3 Protein, His Tag
Mouse
HEK293
SDS-PAGE
ELISA

$360.00

100ug
Siglec-15
SG5-R52H3
Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)
Rat
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
NC-318NC-318; 5G-12Phase 2 ClinicalYale School Of Medicine
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Endometrial Neoplasms; Lung Neoplasms; Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck
Details
DS-1501DS-1501Phase 1 ClinicalDaiichi Sankyo Co Ltd
Osteoporosis
Details
BSI-060TPYX-106; BSI-060TPhase 1 ClinicalBiosion Inc
Neoplasm Metastasis; Solid tumours
Details
Customer Reviews
  • 1***22019-10-11
    Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
    Siglec-15 is a relatively new type of immune checkpoint molecule. In the process of antibody molecule screening, we used ACRO's Siglec-15 antigen. It has shown very good stability in protein-level binding experiments, and the bioactivity was also quite good which was verified in functional experiments.
  • 1***32019-10-11
    Human Siglec-15 / CD33L3 Protein, His Tag, low endotoxin (MALS verified)
    The product is pretty good and the price is competitive. Besides, the delivery was fast. In particular, there is a literature introduction cited the product. It is obvious that each target has been carefully studied.
  • 1***22019-10-12
    Human Siglec-15 / CD33L3 Protein, Fc Tag
    We can obtain a good inhibitory effect using this protein to verify its inhibitory on T-cells functions. S15-hFc protein can effectively inhibit the secretion of IFN-gamma stimulated by OKT3 in CD4 + T cells.