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TGF-beta RII

TGF-beta RII

TGF-beta RII Overview

Molecule Name
Transforming growth factor beta receptor 2
Synonyms
TGFBR2,TGFR2,TbetaR-II,TGFβR2
Drug Development Progress
Drugs in Clinical Trials8
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
Background
TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII Product List

Species
  • Human（5）
  • Mouse（1）
Tag
  • His Tag & Avi Tag（2）
  • Fc Tag（1）
  • Fc Tag & Avi Tag（1）
  • His Tag（1）
  • Llama IgG Fc Tag（1）
Host
  • HEK293（6）
Conjugate
  • Biotin-labeled（3）
  • Unconjugated（3）
Grade
  • RUO（6）
Low Endotoxin
  • Yes（2）
  • No（4）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&PriceAdd to Cart
TGF-beta RII
HOTAvitag
TG2-M82H5
Biotinylated Mouse TGF-beta RII / TGFBR2 Protein, His,Avitag™ (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISA

$415.00

25ug
TGF-beta RII
HOTAvitag
TG2-H82E4
Biotinylated Human TGF-beta RII / TGFBR2 Protein, His,Avitag™ (HPLC verified)
Human
HEK293
HPLCSDS-PAGE
ELISA

$380.00

25ug
TGF-beta RII
HOT
TG2-H52H5
Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$375.00

100ug
TGF-beta RII
TG2-H5252
Human TGF-beta RII / TGFBR2 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISABLI

$360.00

100ug
TGF-beta RII
TG2-H5253
Human TGF-beta RII / TGFBR2 Protein, Llama IgG2b Fc Tag, low Endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
TGF-beta RII
Avitag
TG2-H82F6
Biotinylated Human TGF-beta RII / TGFBR2 Protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
INCA-33890INCA33890; INCA-33890Phase 3 ClinicalIncyte Corp
Colorectal Neoplasms; Ovarian Neoplasms; Solid tumours
Details
HCW-9218HCW-9218Phase 2 ClinicalHCW Biologics Inc
Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Fibrosis; Solid tumours
Details
TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center)Phase 2 ClinicalThe University Of Texas MD Anderson Cancer Center
Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis
Details
TGFBR2 KO CAR27/IL-15 NK cells therapy (The University Of Texas MD Anderson Cancer Center)Phase 2 ClinicalThe University Of Texas MD Anderson Cancer Center
Hodgkin Disease; Lymphatic Diseases; Pancreatic Neoplasms
Details
TGFBR-2 KO CD70 CAR NK cell therapy (The University Of Texas MD Anderson Cancer Center)Phase 1 ClinicalThe University Of Texas MD Anderson Cancer Center
Adenocarcinoma, Clear Cell
Details
Autologous TGF-betaR2KO/IL13R-alpha2-CAR T cells Therapy(City of Hope Medical Center)Phase 1 ClinicalCity Of Hope National Medical Center
Astrocytoma; Glioblastoma
Details
RG-6315RG-6315Phase 1 ClinicalGenentech Inc
Scleroderma, Systemic
Details
TASO-001TASO-001; ATB-301Phase 1 ClinicalAutotelicbio Co Ltd
Solid tumours
Details
Customer Reviews
  • A***n2022-07-30
    Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
    I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.