Select Language
Free Registration

TRAIL

TRAIL Overview

English NameTumor necrosis factor ligand superfamily member 10Approved Drugs0
Drugs in Clinical Trials1Target SynonymCD253，Apo-2 ligand，TNFSF10，TNF Superfamily Member 10，APO2L，Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta，Tumor Necrosis Factor Ligand Superfamily Member 10，Tumor Necrosis Factor (Ligand) Family， Member 10，TNF-Related Apoptosis Inducing Ligand TRAIL，TNF-Related Apoptosis-Inducing Ligand，Tumor Necrosis Factor Ligand 6A，CD253 Antigen，Protein TRAIL，TNLG6A，TL2，TRAIL，Apo-2L，Tumor Necrosis Factor (Ligand) Superfamily， Member 10，Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10，Tumor Necrosis Factor Superfamily Member 10
Highest Development StagePhase 2 Clinical
English NameTumor necrosis factor ligand superfamily member 10
Target SynonymCD253，Apo-2 ligand，TNFSF10，TNF Superfamily Member 10，APO2L，Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta，Tumor Necrosis Factor Ligand Superfamily Member 10，Tumor Necrosis Factor (Ligand) Family， Member 10，TNF-Related Apoptosis Inducing Ligand TRAIL，TNF-Related Apoptosis-Inducing Ligand，Tumor Necrosis Factor Ligand 6A，CD253 Antigen，Protein TRAIL，TNLG6A，TL2，TRAIL，Apo-2L，Tumor Necrosis Factor (Ligand) Superfamily， Member 10，Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10，Tumor Necrosis Factor Superfamily Member 10
Approved Drugs0
Drugs in Clinical Trials1
Highest Development StagePhase 2 Clinical

TRAIL Product List

  • Product Category

    Protein (2)

  • Product Status

    Launched (2)

  • Species

    Human (2)

  • Tag

    Fc Tag (1)His Tag (1)

  • Conjugate

    Unconjugated (2)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
TRL-H5243
Human
HEK293
Human TRAIL / TNFSF10 Protein, His Tag, active trimer (MALS verified)
TRL-H5263
Human
HEK293
Human TRAIL / TNFSF10 Protein, Fc Tag, active trimer (MALS verified)
Total: 2
  • 1

TRAIL Background

TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

TRAIL Synonyms

Apo-2L,TRAIL,CD253,TNFSF10,Apo-2 ligand

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
AS-1501AS-1501Phase 1 ClinicalShenzhen Zhongke Ai Shen Pharmaceutical Co LtdLiver Failure; Hepatitis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Hepatic Insufficiency
Details
  • Overview
  • Product List
  • Clinical Drug Information
Share to:

Join UsLegalSite MapPrivacy PolicyTerms and Conditions
Website Feedback
Contact Us

[North America]: +1 800-810-0816
[Switzerland]: +41 800 040 012
[Asia & Pacific]: +86 400-682-2521

order@acrobiosystems.com

[North America]: 1 Innovation Way, Newark, DE 19711, USA
[Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland