TWEAK R

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TWEAK R Overview

Molecule Name

Tumor necrosis factor receptor superfamily member 12A

Synonyms

TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266

Drug Development Progress

Drugs in Clinical Trials0

Approved Drugs0

Highest Development StagePending

Target Synonym

FGF-inducible 14，TWEAK Receptor，Tumor Necrosis Factor Receptor Superfamily， Member 12A，CD266 Antigen，FN14，TNF Receptor Superfamily Member 12A，Type I Transmembrane Protein Fn14，TNR12，Tweak-receptor，TweakR，Fibroblast growth factor-inducible immediate-early response protein 14，Tumor necrosis factor receptor superfamily member 12A，CD266，TNFRSF12A

Background

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.