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Human CCL19 / MIP-3 beta Protein, Tag Free (HPLC verified)

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Cat. No. / Size
Price
Qty
CC9-H5215-50ug
$360.00
CC9-H5215-1mg
$2945.00
ETA of in-stock products:2 business days
Sub-Total$ 0

Product Details

  • Synonym

    CCL19, MIP-3 beta, MIP-3-beta, ELC, MIP3B, SCYA19, EBI1 ligand chemokine

  • Source

    Human CCL19, Tag Free (CC9-H5215) is expressed from human 293 cells (HEK293). It contains AA Gly 22 - Ser 98 (Accession # Q99731-1).

    Predicted N-terminus: Gly 22

    Request for sequence
  • Molecular Characterization

    CCL19 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 8.8 kDa. The protein migrates as 11-12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CCL19 SDS-PAGE

    Human CCL19, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    CCL19 SEC-HPLC

    The purity of Human CCL19, Tag Free (Cat. No. CC9-H5215) was greater than 95% as determined by SEC-HPLC.

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Background

C-C motif chemokine 19(CCL19) is as known as CK beta-11, ELC, MIP3B and SCYA19. May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Recent Advances

 
Drug Development Progress
  • English Name:

    C-C motif chemokine 19

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Phase 1 Clinical

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