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Human CXCL1 Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
CX1-H5253-100ug
$360.00
CX1-H5253-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days
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Product Details

  • Synonym

    Growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO1, SCYB1

  • Source

    Human CXCL1, Fc Tag (CX1-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 35 - Asn 107 (Accession # P09341).

    Predicted N-terminus: Ala 35

    Request for sequence
  • Molecular Characterization

    CXCL1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 34.3 kDa. The protein migrates as 37-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CXCL1 SDS-PAGE

    Human CXCL1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CXCL1 SEC-MALS

    The purity of Human CXCL1, Fc Tag (Cat. No. CX1-H5253) is more than 95% and the molecular weight of this protein is around 60-75 kDa verified by SEC-MALS.

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Background

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small molecule of cytokines belonging to the CXC chemokine family. Also known as growth-regulated oncogene alpha (Growth-regulated oncogene alpha, GROα). It's also known as keratinocytes-derived chemokine (KC) in mice or cytokine-induced neutrophil chemoattractant type-1 (CINC-1) in rats. In humans, this protein is encoded by the gene Cxcl1 and is located on human chromosome 4 among genes for other CXC chemokines. The chemokine CXCL1 is expressed by macrophages, neutrophils and epithelial cells. The chemokine CXCL1 has a chemotactic effect on neutrophils. CXCL1 binds to the chemokine receptor CXCR2 and plays a role in cell chemotaxis. Human CXCL1 is clustered on chromosome 4 adjacent to many CXC chemokine genes. Major roles of CXCL1 include neovascularization, inflammation, wound healing, and tumorigenesis

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