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IFN-alpha/beta R1
IFN-alpha/beta R1 Overview
| English Name | Interferon-alpha/beta receptor alpha chain | Approved Drugs | 5 |
| Drugs in Clinical Trials | 0 | Target Synonym | IFNBR，IFN-Alpha-REC，Beta-Type Antiviral Protein，IFNAR，Cytokine Receptor Class-II Member 1，Interferon Receptor 1，IFNAR1，Interferon Alpha/Beta Receptor 1，Interferon Alpha And Beta Receptor Subunit 1，Type I Interferon Receptor 1，Interferon (Alpha， Beta And Omega) Receptor 1，Alpha-Type Antiviral Protein，IFN-Alpha/Beta Receptor 1，AVP，Interferon-Beta Receptor 1，IFRC，IFN-R-1，CRF2-1，Cytokine Receptor Family 2 Member 1，Interferon-Alpha/Beta Receptor Alpha Chain |
| Highest Development Stage | Approved | ||
| English Name | Interferon-alpha/beta receptor alpha chain |
| Target Synonym | IFNBR，IFN-Alpha-REC，Beta-Type Antiviral Protein，IFNAR，Cytokine Receptor Class-II Member 1，Interferon Receptor 1，IFNAR1，Interferon Alpha/Beta Receptor 1，Interferon Alpha And Beta Receptor Subunit 1，Type I Interferon Receptor 1，Interferon (Alpha， Beta And Omega) Receptor 1，Alpha-Type Antiviral Protein，IFN-Alpha/Beta Receptor 1，AVP，Interferon-Beta Receptor 1，IFRC，IFN-R-1，CRF2-1，Cytokine Receptor Family 2 Member 1，Interferon-Alpha/Beta Receptor Alpha Chain |
| Approved Drugs | 5 |
| Drugs in Clinical Trials | 0 |
| Highest Development Stage | Approved |
IFN-alpha/beta R1 Product List
- Product Category
Protein (9)
- Product Status
Launched (9)
- Species
Human (7)Mouse (1)Cynomolgus (1)
- Tag
Fc Tag (1)His Tag (5)His Tag & Avi Tag (3)
- Conjugate
Unconjugated (6)Biotin-labeled (3)
Total: 9
- 1
IFN-alpha/beta R1 Background
Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
IFN-alpha/beta R1 Synonyms
IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Interferon beta (Toray/Daiichi Sankyo) | DL-8234 | Approved | Toray Industries Inc | Feron | Japan | Medulloblastoma; Melanoma; Hepatitis C; Astrocytoma; Glioblastoma; Hepatitis B | null | 1985-04-01 | Medulloblastoma; Glioblastoma; Hepatitis B; Hepatitis C; Astrocytoma; Melanoma | Details |
| Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering) | Approved | Harbin Pharmaceutical Group Holding Co Ltd | 里亚美, 利分能 | Mainland China | Hepatitis, Viral, Human; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Condylomata Acuminata; Varicella Zoster Virus Infection | Harbin Pharmaceutical Group Pharmaceutical Co Ltd | 1996-01-01 | Leukemia, Myelogenous, Chronic; Leukemia, Hairy Cell; Varicella Zoster Virus Infection; Multiple Myeloma; Hepatitis, Viral, Human; Lymphoma, Non-Hodgkin; Condylomata Acuminata | Details | |
| Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical) | Approved | Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd | Fu Li Sheng | Leukemia, Hairy Cell; Hepatitis; Multiple Myeloma; Leukemia, Myeloid, Chronic-Phase; Lymphoma, Non-Hodgkin; Herpes Zoster; Condylomata Acuminata | Details | |||||
| Anifrolumab | MDX-1333; MEDI-546 | Approved | Medimmune Llc, Medarex Inc | SAPHNELO | United States | Lupus Erythematosus, Systemic | Astrazeneca Ab | 2021-07-30 | Polymyositis; Hidradenitis; Dermatomyositis; Myositis; Atherosclerosis; Scleroderma, Systemic; Lupus Erythematosus, Cutaneous; Sjogren's Syndrome; Autoimmune Diseases; Lupus Nephritis; Lupus Erythematosus, Systemic; Cardiovascular Diseases; Hidradenitis Suppurativa; Vitiligo | Details |
| Recombinant human interferon α2b biosimilar (Zhejiang Hansheng) | Approved | Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma | 莱福隆 | Mainland China | Virus Diseases; Neoplasms | Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma | 1999-01-01 | Virus Diseases; Neoplasms | Details |
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